Lactate-malate transhydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a lactate---malate transhydrogenase (EC 1.1.99.7) is an enzyme that catalyzes the chemical reaction

(S)-lactate + oxaloacetate pyruvate + malate

Thus, the two substrates of this enzyme are (S)-lactate and oxaloacetate, whereas its two products are pyruvate and malate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-lactate:oxaloacetate oxidoreductase. This enzyme is also called malate-lactate transhydrogenase. This enzyme participates in pyruvate metabolism. It employs one cofactor, nicotinamide D-ribonucleotide.

[edit] References

• IUBMB entry for 1.1.99.7
• BRENDA references for 1.1.99.7 (Recommended.)
• PubMed references for 1.1.99.7
• PubMed Central references for 1.1.99.7
• Google Scholar references for 1.1.99.7
• Allen SH (1966). "The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus". J. Biol. Chem. 241: 5266–75. PMID 4289051. 
• Allen SH, Patil JR (1972). "Studies on the structure and mechanism of action of the malate-lactate transhydrogenase". J. Biol. Chem. 247: 909–16. PMID 4333516. 

[edit] External links

The CAS registry number for this enzyme class is 9077-15-0.

• IUBMB entry for 1.1.99.7

• KEGG entry for 1.1.99.7

• BRENDA entry for 1.1.99.7

• NiceZyme view of 1.1.99.7

• EC2PDB: PDB structures for 1.1.99.7

• PRIAM entry for 1.1.99.7

• PUMA2 entry for 1.1.99.7

• IntEnz: Integrated Enzyme entry for 1.1.99.7

• MetaCyc entry for 1.1.99.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050042: lactate-malate transhydrogenase

• AMIGO entry for GO code 0050042: lactate-malate transhydrogenase