LACRT

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Lacritin
Identifiers
Symbol(s) LACRT; MGC71934
External IDs OMIM: 607360 HomoloGene: 88949
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 90070 n/a
Ensembl ENSG00000135413 n/a
Uniprot Q9GZZ8 n/a
Refseq NM_033277 (mRNA)
NP_150593 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 12: 53.31 - 53.31 Mb n/a
Pubmed search [1] n/a

Lacritin, also known as LACRT, is a human gene.[1]

The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium.[1]

An accurate representation of lacritin's mRNA expression pattern can be seen at NCBI Unigene EST Profile Viewer Hs.307096-LACRT:Lacritin.

[edit] References

  1. ^ a b Entrez Gene: LACRT lacritin.

[edit] Further reading

  • Sanghi S, Kumar R, Lumsden A, et al. (2001). "cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland.". J. Mol. Biol. 310 (1): 127–39. doi:10.1006/jmbi.2001.4748. PMID 11419941. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kumar R, Huebner A, Laurie GW (2003). "Genetic separation of the human lacritin gene ("LACRT") and triple A (Allgrove) syndrome on 12q13.". Adv. Exp. Med. Biol. 506 (Pt A): 167–74. PMID 12613904. 
  • Weigelt B, Bosma AJ, van 't Veer LJ (2004). "Expression of a novel lacrimal gland gene lacritin in human breast tissues.". J. Cancer Res. Clin. Oncol. 129 (12): 735–6. doi:10.1007/s00432-003-0514-y. PMID 14574570. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts.". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. doi:10.1167/iovs.04-1380. PMID 15851553. 
  • Koo BS, Lee DY, Ha HS, et al. (2005). "Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis.". J. Proteome Res. 4 (3): 719–24. doi:10.1021/pr0498133. PMID 15952718. 
  • Tsai PS, Evans JE, Green KM, et al. (2006). "Proteomic analysis of human meibomian gland secretions.". The British journal of ophthalmology 90 (3): 372–7. doi:10.1136/bjo.2005.080846. PMID 16488965. 
  • Ramachandran P, Boontheung P, Xie Y, et al. (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002. 
  • Zhou L, Beuerman RW, Foo Y, et al. (2007). "Characterisation of human tear proteins using high-resolution mass spectrometry.". Ann. Acad. Med. Singap. 35 (6): 400–7. PMID 16865190. 
  • Wang J, Wang N, Xie J, et al. (2006). "Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways.". J. Cell Biol. 174 (5): 689–700. doi:10.1083/jcb.200605140. PMID 16923831. 
  • Ma P, Beck SL, Raab RW, et al. (2006). "Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin.". J. Cell Biol. 174 (7): 1097–106. doi:10.1083/jcb.200511134. PMID 16982797. 
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