Labetalol
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Labetalol
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| Systematic (IUPAC) name | |
| 2-hydroxy-5-[1-hydroxy-2- (4-phenylbutan-2-ylamino)-ethyl]-benzamide |
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| Identifiers | |
| CAS number | |
| ATC code | C07 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H24N2O3 |
| Mol. mass | 328.406 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 90-100% |
| Protein binding | 50% |
| Metabolism | hepatic pass metabolism, |
| Half life | Tablet: 6-8 hours; IV: 5.5 hours |
| Excretion | Excreted in urine, not removed by hemodialysis |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status |
℞ Prescription only |
| Routes | oral iv |
Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance.
It has a particular indication in the treatment of pregnancy-induced hypertension.
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[edit] Administration
Labetalol is available in 100, 200, and 300 mg tablets and intravenously (only as Trandate) in 5 mg/ml solution. Adults taking tablets usually start with 100 mg two times a day, with a maximum of 2.4 g/day. In an emergency situation, this may be higher. IV doses are usually started at 20mg over 2 minutes. Additional doses of 40mg, then 80mg may be administered every ten minutes as needed. Additional 80mg doses can be given to a total maximum dose of 300 mg. Additionally, Labetalol can be administered by IV infusion at a rate of 2mg/minute, with a maximum dose of 300mg.
[edit] Side effects
Side effects may include:
- Drowsiness
- Fatigue
- Weakness
- Difficulty sleeping
- Diminished sexual function
- Scalp tingling which passes after time.
- A rare but potentially lethal side effect is respiratory distress.
[edit] Contraindications
Labetalol should not be used in patients that have asthma, congestive heart failure, any degree of heart blocks, slow heart rates or those in cardiogenic shock
[edit] References
- Hodgson, Barbara B., and Kizior, Robert J. Saunders Nursing Drug Handbook 2006. St. Louis, MO: Elsevier, Saunders, 2006. bledsoe "prehospital emergency pharmacology" upper Saddle River, New Jersey: Pearson 2005
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