L3MBTL

From Wikipedia, the free encyclopedia


L(3)mbt-like (Drosophila)
PDB rendering based on 1oyx.
Available structures: 1oyx, 1oz2, 1oz3
Identifiers
Symbol(s) L3MBTL; DKFZp586P1522; FLJ41181; H-L(3)MBT; KIAA0681; L3MBTL1; dJ138B7.3
External IDs OMIM: 608802 MGI2676663 HomoloGene41846
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 26013 241764
Ensembl ENSG00000185513 ENSMUSG00000035576
Uniprot Q9Y468 n/a
Refseq NM_015478 (mRNA)
NP_056293 (protein)
XM_895109 (mRNA)
XP_900202 (protein)
Location Chr 20: 41.58 - 41.6 Mb Chr 2: 162.64 - 162.67 Mb
Pubmed search [1] [2]

L(3)mbt-like (Drosophila), also known as L3MBTL, is a human gene.[1]

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

[edit] References

[edit] Further reading

  • Trojer P, Li G, Sims RJ, et al. (2007). "L3MBTL1, a histone-methylation-dependent chromatin lock.". Cell 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • MacGrogan D, Kalakonda N, Alvarez S, et al. (2004). "Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells.". Genes Chromosomes Cancer 41 (3): 203–13. doi:10.1002/gcc.20087. PMID 15334543. 
  • Li J, Bench AJ, Vassiliou GS, et al. (2004). "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies.". Proc. Natl. Acad. Sci. U.S.A. 101 (19): 7341–6. doi:10.1073/pnas.0308195101. PMID 15123827. 
  • Wang WK, Tereshko V, Boccuni P, et al. (2004). "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets.". Structure 11 (7): 775–89. PMID 12842041. 
  • Boccuni P, MacGrogan D, Scandura JM, Nimer SD (2003). "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Koga H, Matsui S, Hirota T, et al. (1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes.". Oncogene 18 (26): 3799–809. doi:10.1038/sj.onc.1202732. PMID 10445843. 
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.