L-threonine 3-dehydrogenase
From Wikipedia, the free encyclopedia
In enzymology, a L-threonine 3-dehydrogenase (EC 1.1.1.103) is an enzyme that catalyzes the chemical reaction
- L-threonine + NAD+
L-2-amino-3-oxobutanoate + NADH + H+
Thus, the two substrates of this enzyme are L-threonine and NAD+, whereas its 3 products are L-2-amino-3-oxobutanoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-threonine:NAD+ oxidoreductase. Other names in common use include L-threonine dehydrogenase, threonine 3-dehydrogenase, and threonine dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2D8A, 2DFV, and 2DQ4.
[edit] References
- IUBMB entry for 1.1.1.103
- BRENDA references for 1.1.1.103 (Recommended.)
- PubMed references for 1.1.1.103
- PubMed Central references for 1.1.1.103
- Google Scholar references for 1.1.1.103
- Green ML, Elliott WH (1964). "The enzymic formation of aminoacetone from threonine and its further metabolism". Biochem. J. 92: 537–49. PMID 4284408.
- HARTSHORNE D, GREENBERG DM (1964). "STUDIES ON LIVER THREONINE DEHYDROGENASE". Arch. Biochem. Biophys. 105: 173–8. doi:. PMID 14165492.
[edit] External links
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- The CAS registry number for this enzyme class is 9067-99-6.
[edit] Gene Ontology (GO) codes
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