L-threonate 3-dehydrogenase

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In enzymology, a L-threonate 3-dehydrogenase (EC 1.1.1.129) is an enzyme that catalyzes the chemical reaction

L-threonate + NAD⁺ 3-dehydro-L-threonate + NADH + H⁺

Thus, the two substrates of this enzyme are L-threonate and NAD⁺, whereas its 3 products are 3-dehydro-L-threonate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-threonate:NAD+ 3-oxidoreductase. Other names in common use include threonate dehydrogenase, and L-threonic acid dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

[edit] References

• IUBMB entry for 1.1.1.129
• BRENDA references for 1.1.1.129 (Recommended.)
• PubMed references for 1.1.1.129
• PubMed Central references for 1.1.1.129
• Google Scholar references for 1.1.1.129
• ASPEN AJ, JAKOBY WB (1964). "L-THREONIC ACID DEHYDROGENASE: PURIFICATION AND PROPERTIES". J. Biol. Chem. 239: 710–3. PMID 14154441. 

[edit] External links

The CAS registry number for this enzyme class is 37250-59-2.

• IUBMB entry for 1.1.1.129

• KEGG entry for 1.1.1.129

• BRENDA entry for 1.1.1.129

• NiceZyme view of 1.1.1.129

• EC2PDB: PDB structures for 1.1.1.129

• PRIAM entry for 1.1.1.129

• PUMA2 entry for 1.1.1.129

• IntEnz: Integrated Enzyme entry for 1.1.1.129

• MetaCyc entry for 1.1.1.129

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050036: L-threonate 3-dehydrogenase

• AMIGO entry for GO code 0050036: L-threonate 3-dehydrogenase