L-myc internal ribosome entry site (IRES)

From Wikipedia, the free encyclopedia

L-myc internal ribosome entry site (IRES)

Type:	Cis-reg; IRES;
2° structure:	Published; PubMed
Seed alignment:	14730027&dopt=Abstract PubMed
Avg length:	220.2 nucleotides
Avg identity:	94%

The L-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of L-myc that allows cap-independent translation. L-myc undergoes translation via the internal ribosome entry site and bypasses the typical eukaryotic cap-dependent translation pathway [1]. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis.

[edit] References

[1] Jopling, CL; Spriggs KA, Mitchell SA, Stoneley M, Willis AE (2004). "L-Myc protein synthesis is initiated by internal ribosome entry". RNA 10: 287–298. doi:10.1261/rna.5138804. PMID 14730027.