L-iditol 2-dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a L-iditol 2-dehydrogenase (EC 1.1.1.14) is an enzyme that catalyzes the chemical reaction

L-iditol + NAD⁺ $\rightleftharpoons$ L-sorbose + NADH + H⁺

Thus, the two substrates of this enzyme are L-iditol and NAD⁺, whereas its 3 products are L-sorbose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-iditol:NAD+ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD+ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD+ oxidoreductase, NAD+-dependent sorbitol dehydrogenase, NAD+-dependent sorbitol dehydrogenase, and NAD+-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1K2W, 1PL6, 1PL7, and 1PL8.

[edit] References

IUBMB entry for 1.1.1.14
BRENDA references for 1.1.1.14 (Recommended.)
PubMed references for 1.1.1.14
PubMed Central references for 1.1.1.14
Google Scholar references for 1.1.1.14
Bailey JP, Renz C and McGuinness ET (1981). "Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties". Comp. Biochem. Physiol. 69B: 909–914.
Burnell JN, Holmes RS (1983). "Purification and properties of sorbitol dehydrogenase from mouse liver". Int. J. Biochem. 15: 507–11. doi:10.1016/0020-711X(83)90124-6. PMID 6852349.
Leissing N, McGuinness ET (1978). "Rapid affinity purification and properties of rat liver sorbitol dehydrogenase". Biochim. Biophys. Acta. 524: 254–61. PMID 667078.
Negm FB and Loescher WH (1979). "Detection and characterization of sorbitol dehydrogenase from apple callus tissue". Plant Physiol. 64: 69–73.
O'Brien MM, Schofield PJ, Edwards MR (1983). "Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase". Biochem. J. 211: 81–90. PMID 6870831.