L-fuculose-phosphate aldolase

From Wikipedia, the free encyclopedia

In enzymology, a L-fuculose-phosphate aldolase (EC 4.1.2.17) is an enzyme that catalyzes the chemical reaction

L-fuculose-1-phosphate glycerone phosphate + (S)-lactaldehyde

Hence, this enzyme has one substrate, L-fuculose-1-phosphate, and two products, glycerone phosphate and (S)-lactaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-fuculose-1-phosphate (S)-lactaldehyde-lyase (glycerone-phosphate-forming). Other names in common use include L-fuculose 1-phosphate aldolase, fuculose aldolase, and L-fuculose-1-phosphate lactaldehyde-lyase. This enzyme participates in fructose and mannose metabolism.

Contents 1 Structural studies 2 See also 3 References 4 External links 4.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes 1DZU, 1DZV, 1DZW, 1DZX, 1DZY, 1DZZ, 1E46, 1E47, 1E48, 1E49, 1E4A, 1E4B, 1E4C, 1FUA, 2FK5, 2FLF, 2FUA, 2OPI, 3FUA, and 4FUA.

[edit] See also

• Fuculose
• L-Fuculose kinase (abbreviated FucK)

[edit] References

• IUBMB entry for 4.1.2.17
• BRENDA references for 4.1.2.17 (Recommended.)
• PubMed references for 4.1.2.17
• PubMed Central references for 4.1.2.17
• Google Scholar references for 4.1.2.17
• Ghalambor MA, Heath EC (1966). "The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase". J. Biol. Chem. 241: 3216–21. PMID 5330266. 
• Dreyer MK, Schulz GE (1993). "The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli". J. Mol. Biol. 231: 549–53. doi:10.1006/jmbi.1993.1307. PMID 8515438. 
• Dreyer MK, Schulz GE (1996). "Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure". J. Mol. Biol. 259: 458–66. doi:10.1006/jmbi.1996.0332. PMID 8676381. 

[edit] External links

The CAS registry number for this enzyme class is 9024-54-8.

• IUBMB entry for 4.1.2.17

• KEGG entry for 4.1.2.17

• BRENDA entry for 4.1.2.17

• NiceZyme view of 4.1.2.17

• EC2PDB: PDB structures for 4.1.2.17

• PRIAM entry for 4.1.2.17

• PUMA2 entry for 4.1.2.17

• IntEnz: Integrated Enzyme entry for 4.1.2.17

• MetaCyc entry for 4.1.2.17

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008738: L-fuculose-phosphate aldolase

• AMIGO entry for GO code 0008738: L-fuculose-phosphate aldolase