L-dopachrome isomerase

From Wikipedia, the free encyclopedia

In enzymology, a L-dopachrome isomerase (EC 5.3.3.12) is an enzyme that catalyzes the chemical reaction

L-dopachrome $\rightleftharpoons$ 5,6-dihydroxyindole-2-carboxylate

Hence, this enzyme has one substrate, L-dopachrome, and one product, 5,6-dihydroxyindole-2-carboxylate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is L-dopachrome keto-enol isomerase. Other names in common use include dopachrome tautomerase, tyrosinase-related protein 2, TRP-1, TRP2, TRP-2, tyrosinase-related protein-2, dopachrome Delta7,Delta2-isomerase, dopachrome Delta-isomerase, dopachrome conversion factor, dopachrome isomerase, dopachrome oxidoreductase, dopachrome-rearranging enzyme, DCF, DCT, dopachrome keto-enol isomerase, and L-dopachrome-methyl ester tautomerase. This enzyme participates in tyrosine metabolism and melanogenesis.

[edit] References

IUBMB entry for 5.3.3.12
BRENDA references for 5.3.3.12 (Recommended.)
PubMed references for 5.3.3.12
PubMed Central references for 5.3.3.12
Google Scholar references for 5.3.3.12
Jara JR, Lozano JA (Pt 2). "Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase". Biochem. J. 313: 447–53. PMID 8573077.
Pawelek JM (1990). "Dopachrome conversion factor functions as an isomerase". Biochem. Biophys. Res. Commun. 166: 1328–33. doi:10.1016/0006-291X(90)91011-G. PMID 2106316.
Joshua GW, Selkirk ME, Zhang Y, Meyer DJ (Pt 3). "Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi". Biochem. J. 335: 495–8. PMID 9794786.