L-aspartate oxidase

From Wikipedia, the free encyclopedia

In enzymology, a L-aspartate oxidase (EC 1.4.3.16) is an enzyme that catalyzes the chemical reaction

L-aspartate + H₂O + O₂ oxaloacetate + NH₃ + H₂O₂

The 3 substrates of this enzyme are L-aspartate, H₂O, and O₂, whereas its 3 products are oxaloacetate, NH₃, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is L-aspartate:oxygen oxidoreductase (deaminating). This enzyme participates in alanine and aspartate metabolism and nicotinate and nicotinamide metabolism. It employs one cofactor, FAD.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1J5P, 1KNP, and 1KNR.

[edit] References

• IUBMB entry for 1.4.3.16
• BRENDA references for 1.4.3.16 (Recommended.)
• PubMed references for 1.4.3.16
• PubMed Central references for 1.4.3.16
• Google Scholar references for 1.4.3.16
• Nasu S, Wicks FD, Gholson RK (1982). "L-Aspartate oxidase, a newly discovered enzyme of Escherichia coli, is the B protein of quinolinate synthetase". J. Biol. Chem. 257: 626–32. PMID 7033218. 

[edit] External links

The CAS registry number for this enzyme class is 69106-47-4.

• IUBMB entry for 1.4.3.16

• KEGG entry for 1.4.3.16

• BRENDA entry for 1.4.3.16

• NiceZyme view of 1.4.3.16

• EC2PDB: PDB structures for 1.4.3.16

• PRIAM entry for 1.4.3.16

• PUMA2 entry for 1.4.3.16

• IntEnz: Integrated Enzyme entry for 1.4.3.16

• MetaCyc entry for 1.4.3.16

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008734: L-aspartate oxidase

• AMIGO entry for GO code 0008734: L-aspartate oxidase