L-ascorbate oxidase

From Wikipedia, the free encyclopedia

In enzymology, a L-ascorbate oxidase (EC 1.10.3.3) is an enzyme that catalyzes the chemical reaction

2 L-ascorbate + O₂ 2 dehydroascorbate + 2 H₂O

Thus, the two substrates of this enzyme are L-ascorbate and O₂, whereas its two products are dehydroascorbate and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with oxygen as acceptor. The systematic name of this enzyme class is L-ascorbate:oxygen oxidoreductase. Other names in common use include ascorbase, ascorbic acid oxidase, ascorbate oxidase, ascorbic oxidase, ascorbate dehydrogenase, L-ascorbic acid oxidase, AAO, L-ascorbate:O2 oxidoreductase, and AA oxidase. This enzyme participates in ascorbate metabolism. It employs one cofactor, copper.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1AOZ, 1ASO, 1ASP, and 1ASQ.

[edit] References

• IUBMB entry for 1.10.3.3
• BRENDA references for 1.10.3.3 (Recommended.)
• PubMed references for 1.10.3.3
• PubMed Central references for 1.10.3.3
• Google Scholar references for 1.10.3.3
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 297-311.

[edit] External links

The CAS registry number for this enzyme class is 9029-44-1.

• IUBMB entry for 1.10.3.3

• KEGG entry for 1.10.3.3

• BRENDA entry for 1.10.3.3

• NiceZyme view of 1.10.3.3

• EC2PDB: PDB structures for 1.10.3.3

• PRIAM entry for 1.10.3.3

• PUMA2 entry for 1.10.3.3

• IntEnz: Integrated Enzyme entry for 1.10.3.3

• MetaCyc entry for 1.10.3.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008447: L-ascorbate oxidase

• AMIGO entry for GO code 0008447: L-ascorbate oxidase