L-aminoadipate-semialdehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H₂O L-2-aminoadipate + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include aminoadipate semialdehyde dehydrogenase, 2-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipate reductase, 2-aminoadipic semialdehyde dehydrogenase, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine, and dinucleotide oxidoreductase. This enzyme participates in lysine biosynthesis and lysine degradation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BYD, 2C43, and 2CG5.

[edit] References

• IUBMB entry for 1.2.1.31
• BRENDA references for 1.2.1.31 (Recommended.)
• PubMed references for 1.2.1.31
• PubMed Central references for 1.2.1.31
• Google Scholar references for 1.2.1.31
• Calvert AF, Rodwell VW (1966). "Metabolism of pipecolic acid in a Pseudomonas species. 3 L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase". J. Biol. Chem. 241: 409–14. PMID 4285660. 

[edit] External links

The CAS registry number for this enzyme class is 9067-87-2.

• IUBMB entry for 1.2.1.31

• KEGG entry for 1.2.1.31

• BRENDA entry for 1.2.1.31

• NiceZyme view of 1.2.1.31

• EC2PDB: PDB structures for 1.2.1.31

• PRIAM entry for 1.2.1.31

• PUMA2 entry for 1.2.1.31

• IntEnz: Integrated Enzyme entry for 1.2.1.31

• MetaCyc entry for 1.2.1.31

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004043: L-aminoadipate-semialdehyde dehydrogenase

• AMIGO entry for GO code 0004043: L-aminoadipate-semialdehyde dehydrogenase