L-amino-acid alpha-ligase

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In enzymology, a L-amino-acid alpha-ligase (EC 6.3.2.28) is an enzyme that catalyzes the chemical reaction

ATP + an L-amino acid + an L-amino acid ADP + phosphate + L-aminoacyl-L-amino acid

Thus, the two substrates of this enzyme are ATP and L-amino acid, whereas its 3 products are ADP, phosphate, and L-aminoacyl-L-amino acid.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-amino acid:L-amino acid ligase (ADP-forming). Other names in common use include L-amino acid alpha-ligase, bacilysin synthetase, YwfE, and L-amino acid ligase.

[edit] References

• IUBMB entry for 6.3.2.28
• BRENDA references for 6.3.2.28 (Recommended.)
• PubMed references for 6.3.2.28
• PubMed Central references for 6.3.2.28
• Google Scholar references for 6.3.2.28
• Tabata K, Ikeda H, Hashimoto S (2005). "ywfE in Bacillus subtilis codes for a novel enzyme, L-amino acid ligase". J. Bacteriol. 187: 5195–202. doi:10.1128/JB.187.15.5195-5202.2005. PMID 16030213. 

[edit] External links

• IUBMB entry for 6.3.2.28

• KEGG entry for 6.3.2.28

• BRENDA entry for 6.3.2.28

• NiceZyme view of 6.3.2.28

• EC2PDB: PDB structures for 6.3.2.28

• PRIAM entry for 6.3.2.28

• PUMA2 entry for 6.3.2.28

• IntEnz: Integrated Enzyme entry for 6.3.2.28

• MetaCyc entry for 6.3.2.28

• Atomic-resolution structures of enzymes belonging to this class