Kynurenine-oxoglutarate transaminase
From Wikipedia, the free encyclopedia
In enzymology, a kynurenine-oxoglutarate transaminase (EC 2.6.1.7) is an enzyme that catalyzes the chemical reaction
- L-kynurenine + 2-oxoglutarate
4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
Thus, the two substrates of this enzyme are L-kynurenine and 2-oxoglutarate, whereas its two products are 4-(2-aminophenyl)-2,4-dioxobutanoate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:2-oxoglutarate aminotransferase. Other names in common use include kynurenine transaminase (cyclizing), kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, and L-kynurenine aminotransferase. This enzyme participates in tryptophan metabolism. It employs one cofactor, pyridoxal phosphate.
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[edit] Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1X0M, 1YIY, 1W7L, and 1YIZ.
[edit] References
- IUBMB entry for 2.6.1.7
- BRENDA references for 2.6.1.7 (Recommended.)
- PubMed references for 2.6.1.7
- PubMed Central references for 2.6.1.7
- Google Scholar references for 2.6.1.7
- BONNER DM, JAKOBY WB (1956). "Kynurenine transaminase from neurospora". J. Biol. Chem. 221: 689–95. PMID 13357462.
- MASON M (1957). "Kynurenine transaminase of rat kidney; a study of coenzyme dissociation". J. Biol. Chem. 227: 61–8. PMID 13449053.
[edit] External links
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- The CAS registry number for this enzyme class is 9030-38-0.
[edit] Gene Ontology (GO) codes
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