Kynurenate-7,8-dihydrodiol dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a kynurenate-7,8-dihydrodiol dehydrogenase (EC 1.3.1.18) is an enzyme that catalyzes the chemical reaction

7,8-dihydro-7,8-dihydroxykynurenate + NAD⁺ 7,8-dihydroxykynurenate + NADH + H⁺

Thus, the two substrates of this enzyme are 7,8-dihydro-7,8-dihydroxykynurenate and NAD⁺, whereas its 3 products are 7,8-dihydroxykynurenate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase. Other names in common use include 7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase, and 7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase. This enzyme participates in tryptophan metabolism.

[edit] References

• IUBMB entry for 1.3.1.18
• BRENDA references for 1.3.1.18 (Recommended.)
• PubMed references for 1.3.1.18
• PubMed Central references for 1.3.1.18
• Google Scholar references for 1.3.1.18
• Taniuchi H and Hayaishi O (1963). "Studies on the metabolism of kynurenic acid. III. Enzymatic formation of 7,8-dihydroxykynurenic acid from kynurenic acid". J. Biol. Chem. 238: 283–293. 

[edit] External links

The CAS registry number for this enzyme class is 37255-30-4.

• IUBMB entry for 1.3.1.18

• KEGG entry for 1.3.1.18

• BRENDA entry for 1.3.1.18

• NiceZyme view of 1.3.1.18

• EC2PDB: PDB structures for 1.3.1.18

• PRIAM entry for 1.3.1.18

• PUMA2 entry for 1.3.1.18

• IntEnz: Integrated Enzyme entry for 1.3.1.18

• MetaCyc entry for 1.3.1.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047114: kynurenate-7,8-dihydrodiol dehydrogenase

• AMIGO entry for GO code 0047114: kynurenate-7,8-dihydrodiol dehydrogenase