Talk:Kuru (disease)

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Kuru (disease) was a good article, but it has been removed from the list. There are suggestions below for improving the article to meet the good article criteria. Once these are addressed, the article can be renominated. Editors may also seek a reassessment of the decision if they believe there was a mistake.

Delisted version: November 8, 2006
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Contents

[edit] Western Medicine

I've removed the term "in Western Medicine" from the discussion of the causes, since it's weasle wording. Medicine is (or should be) based upon consideration of the evidence - whether the medics are "Western" or otherwise is irrelevant. —Preceding unsigned comment added by 163.1.176.253 (talk) 12:35, 23 February 2008 (UTC)


[edit] Permissions

Original author's permission to adapt.

Hi Rohan- I would be happy to allow the use of my Kuru paper for the encyclopedia. Is there anything further you need me to do? Do I need to copyright the paper, or do you just need my permission? I'm not quite sure how to handle this type of situation. Let me know and I will assist you in anyway possible.

Thanks! Stacy McGrath

[edit] why cannibalism

I think the article should make some mention of why the South Fore practice(d) cannibalism. My recollection is that upland New Guinea had few indigenous sources of protein, forcing those living there to resort to such measures. I think they incorporated it into their culture, and that one ate ones relatives (although I'm not so sure about this last bit). Equally, the article says kuru "all but disappeared with the termination of cannibalism in New Guinea" - I imagine that once the cause was determined, some program of health education was undertaken (by whom?) which caused said termination. So, in summary, the article should say why the South Fore did it, and why they stopped doing it (maybe only a sentence for each would be sufficient - I realise this is an article about the disease, not a treatise of cultural anthropology). -- Finlay McWalter | Talk 00:35, 22 Jun 2004 (UTC)

Cannibalism stopped when it was made illegal in 1957. The people didn't put up much resistance to the ban, I think because the practice of eating the dead hadn't been going on in their culture for all that long, so it wasn't really a big deal for them to abandon it. Kuru didn't stop with the ban, there are still occasional cases today due to the huge incubation periods. The Fore people also still don't believe in infectious agents - they are convinced kuru was some kind of supernatural punishment or curse. As to why they started practising cannibalism in the first place, having spoken to some people who've been out there I get the impression it was partly because a neighbouring tribe pointed out it was a good source of much needed protein, and partly because they thought it was kind of rude to chuck your relatives in a pit to rot. It became part of the funerary rituals. I will put some of this in when I get round to it! --Purple 17:28, 22 February 2006 (UTC)
Was there a famine at the time they started, that they needed a good source of protein? Plus, what about this neigbouring tribe. Were they affected by Kuru? They must have already practiced it if they were the ones to show it to the South Fore. 24.84.35.186 20:12, 16 July 2006 (UTC)

From what I've been reading in "Guns, Germs, and Steel," the climate of the New Guinean highlands doesn't have any natural sources of protein. There are no large animals in the region that can be eaten. Additionally, high protein crops like wheat and barley won't grow there, and the highlands have little access to oceans and streams, which means no fish either. Protein deficiency was endemic there for hundreds of years, leading to cannibalism. —Preceding unsigned comment added by 24.192.82.87 (talk) 07:15, 9 January 2008 (UTC)

http://www.timesonline.co.uk/tol/life_and_style/health/features/article3215917.ece

Looks like the men escaped because they invented a reason not to eat dead people. The RS lecture should be citeable. It is not impossible that the women were encouraged to become cannibals because they would be "distasteful" to other tribes and less likely to be stolen (see various tatooing and mutilation rituals). —Preceding unsigned comment added by 80.177.22.199 (talk) 22:20, 26 January 2008 (UTC)

[edit] distinct from CJD?

Is this actually a distinct disease from Creutzfeldt-Jakob_disease? It seems like maybe the articles should be merged but maybe these are different rather than two different names for the same disease. Kit 05:08:49, 2005-08-09 (UTC)

They are most certainly distinct. CJD is inherited, and vCJD is CJD from consuming beef. Kuru is a prion disease due to cannibalism, although its persistence is unexplained. Okay, the mechanism is similar, but to merge this with CJD would lead to loss of a vital distinction. JFW | T@lk 16:59, 9 August 2005 (UTC)
Ok, thanks for clarifying. Kit 20:29:06, 2005-08-09 (UTC)
Purple, what do you mean by the "persistence of the Kuru prion"? 24.84.35.186 20:09, 16 July 2006 (UTC)

[edit] Comments

This is one of the best articles I've read. Nicely done.

[edit] In-line references

This article would be better it if were clear which reference supports which statements. The is greatly increases verifiablilty. ike9898 16:36, 10 March 2006 (UTC)

I agree about the referencing. But it is an excellent article. I know a lot about prions and have gone a bit mad editing all the prion pages but I haven't touuched kuru because there's nothing to be done --Purple 02:17, 11 March 2006 (UTC)

[edit] Kuru and prions

I'm not sure if this is the right place to put my question, but I'm doing a research project on the Kuru disease and I'd like to know what exactly prions do that cause the brain to get "spongy".

Now, from reading the Prion article in Wikipedia, I get that the PrP^Sc protein contains a lot more of the amino acid structure called "beta sheets" than the normal PrP^C proteins. Now assuming that HuPrP^Sc kuru protein is somewhat related to the PrP^Sc protein, these "beta sheets" allow the proteins to form insoluble fibrils called amyloid aggregations. How do these fibres cause problems? I'm only a grade 10 student, so I'd like a somewhat simplified answer so that I can understand what you are saying without having to research every word I don't understand. :)

I'd also like to know what exactly amyloid aggregations are. From what I can understand so far, they are structures formed by the prions that cause a heck of a lot of problems. Would I be correct? The article on amyloids in Wikipedia tells me that they are responsible for many neurodegenerative diseases, but it doesn't tell me how the amyloid aggregations cause the problems. Doing some more research on Wikipedia, I found that amyloid aggregations cause problems in people with Alzheimers by braking down blood vessels. Does the same sort of thing happen in Kuru?

I would really appreciate your help.

-Proteins have four levels (primary, secondary, tertiary, and quaternary) of structure. The two most important characteristics of secondary protein structure are alpha-helixes and beta-pleated sheets. A prion is a protein that is somehow misformed (I'm not sure if this malformation has anything to do with beta-pleated sheets or not), and this misformation makes the protein nonfunctional. Through a still unclear mechanism, prions can transmit their structural mistakes to normally structured proteins. The malformation spreads through the proteins of a normal brain after the prions are ingested, and more and more proteins become converted to prions and become nonfunctional. Proteins that don't work will obviously impede cellular functions and cause cell death, destroying brain tissue and creating a "spongy" texture. —Preceding unsigned comment added by 24.192.82.87 (talk) 07:22, 9 January 2008 (UTC)

[edit] Kuru and Cannibalism - the evidence doesn't fit

The connection just isn't there.
1. Kuru has never been successfully transmitted to animals via the alimentary canal, only by direct invasion of the bloodstream. Even Gadjusek, toward the end of his life, stated that there must be some other mode of transmission other than cannibalism. This rather straightforward fact is ignored by those anxious to promote either prion theory or Fore cannibalism. He proposed that handling human brains and then rubbing eyes or picking noses could have caused the spread of the disease. (This is handling corpses, not eating them.) Remember, this is a disease that was causing more than half the deaths in the Fore community, and it seems unlikely that the illness could that widespread given such a haphazard mode of transmission.
2. Neither Gadjusek nor Lindenbaum nor any other researcher ever observed Fore cannibalism. In fact, Gadjusek's journals consistently lament the absence of cannibalism, and when it had occured it "certainly did not involve brains." Even allowing for a prolonged latency period, even Gadjusek admitted that there is no way that the youngest victims had ever eaten human flesh.
3. Kuru is a varient of Creutzfeldt-Jakob's disease, which leads to the question, how is it, and other suspected prion diseases, spread in the West? No one has serious proposed that mad cow disease in England is contracted by cannibalism.
4. Remember, prions are just a theory, and a controversial one. In terms of their relation to theories of universal cannibalism among our ancestors, those theories BEGIN with the potentialy unfounded assumption that the Fore were cannibals, they don't prove it.

-As of now prions are the best explanation we have for many diseases like kuru or mad cow. As for mad cow, most theories suggest that it was caused not by cannibalism among humans, but cannibalism among cows. Many sheep and cattle ranchers found it cheaper to provide protein to their livestock by feeding them ground up meat from other livestock, often including the brain and/or spinal cord. It is also inaccurate to suggest that kuru isn't caused by cannibalism, but by handling bodies. Prions can find their way into the bloodstream through any obvious orifice like eyes etc, but also (because prions are misshapen proteins they are tiny pieces of subcellular machinery) through any minute cuts or scratches at any point in the alimentary canal. Due to their misshapen structure it is easily possible that prions are nonresponsive to the changes in temperature and acidity of the stomach, finding their way in through any breaches in the digestive system. Also, cannibalism leads to an inordinate amount of "handling corpses," so cannibalism is still to blame, even by proxy.

[edit] Additional Info

I remember that the PBS Nova documentary on prions mentioned something about why the women and children were afflicted more often by Kuru than males were. It had something to do with the "good" parts of the corpse and the "bad" parts of the corpse. The males got the "good" parts, which usually consisted of the muscles and fatty organs. The females and children got the "bad" parts, which included the brain and the other less desirable parts. Thus, the women and children directly ingested the prion, which would explain the disproportional distribution of Kuru occurrence between the males and females.
I'm adding this info into the article. I also found the source at the PBS site, so I'm fairly confident in the info.[1] Jumping cheese Contact 03:39, 1 November 2006 (UTC)

[edit] Reasons for GA Delisting

This article's GA status has been revoked because it fails criterion 2. b. of 'What is a Good Article?', which states;

(b) the citation of its sources using inline citations is required (this criterion is disputed by editors on Physics and Mathematics pages who have proposed a subject-specific guideline on citation, as well as some other editors — see talk page).

LuciferMorgan 22:58, 8 November 2006 (UTC)

[edit] So what does it mean?

The opening paragraph translates kuru as both "shaking death" and "trembling with cold and fever" - which is it? --NEMT 04:57, 29 January 2007 (UTC)

Probably both. Words often have multiple translations as they have multiple meaning, just look at a dictionary. 131.91.92.184 (talk) 14:28, 28 January 2008 (UTC)
You're replying to a year-old comment. The only sourced translation is "trembling with fear." Xihr (talk) 23:54, 28 January 2008 (UTC)

[edit] incubation period

All of the victims were born before 1950 indicating that the disease has a long incubation period. The minimum incubation period for many of the victims was between 34 and 41 years.(Collinge, et al., 2006)

In humans, kuru had an incubation period with a minimum of two years and maximum of twenty-three (Gajdusek et al., 1966).

Which is it?

Or should the first quote above be changed to read:

All of the victims were born before 1950 indicating that the disease has a long incubation period. The incubation period for many of the victims was between 34 and 41 years.(Collinge, et al., 2006)

SLATE 03:59, 1 February 2007 (UTC)

This possibility was eventually ruled out because kuru was too common and too fatal (Lindenbaum, 1979) — such a lethal genetic disorder would drastically reduce the fitness of a population and soon die out of the gene pool.

I'm not sure a disease with such a long dormancy period can provide a large enough selection on indiviudals within a population to eliminate such individuals, especially within the timeframe considered here. In other words, the argument Lindenbaum makes (I have not read the original work), that kuru cannot be a genetic disease because it would be eliminated if it were so, is weak at best. Diseases that occur after an individual reaches reproductive age are often very long lived in a population; if not indefinite, they can last many generations.

Zamftb 21:05, 27 February 2007 (UTC)

[edit] The Laughing Sickness in Mayan civilisations

Just saw Apocalypto and there was a scene with a man they described as having "the laughing sickness". He was emaciated and laughing manically. Just curious to know if there is any evidence that kuru was in Mayan cultures, and was this a reference to kuru or is this just Mel Gibson making things up again. Nomadtales 08:58, 19 February 2007 (UTC)

It's a movie. Get over it.Viz 03:57, 9 March 2007 (UTC)

It's a question. Answer it. Nomadtales 09:03, 9 March 2007 (UTC)

[edit] Translation

The first paragraph gives two translations for kuru. --Savant13 21:20, 5 April 2007 (UTC)

[edit] Copyright issues

This article was created (check the history at the link) with content adapted from another author, and used with permission for the encyclopedia as far as the authors statement above references. "Hi Rohan- I would be happy to allow the use of my Kuru paper for the encyclopedia." This means that it's used as fair use under WP:NONFREE and WP:NFCC. Needs to be deleted for the time being, if we can get a free content liscense from the author we can always restore. -70.161.199.196 18:31, 7 August 2007 (UTC)

That makes no sense. If the copyright holder granted permission, why delete? Catchpole 20:39, 7 August 2007 (UTC)
It wasn't licensed, making it just fair-use. Since we are a free encyclopedia, we are supposed to have free articles and not fair-use articles. --Hemlock Martinis 20:53, 7 August 2007 (UTC)
I cannot see what practical difference it makes in this case. Seems like cutting your nose off to spite your face. Catchpole 21:00, 7 August 2007 (UTC)
It makes a huge issue, we distribute the encyclopedia to others, and give them rights to change, distribute, and charge for it if they wish. Look at the logo in the upper right, "The Free Encyclopedia" means free content. -70.161.199.196 22:47, 7 August 2007 (UTC)
I have tried to find contact information for Ms. McGrath (the original author of the work that the deleted version is a derivative work of) but have come up dry. I have sent an email to the former Professor whose page the work is hosted on requesting contact information. --Jeremyb 00:45, 8 August 2007 (UTC)