KSR1

From Wikipedia, the free encyclopedia

Kinase suppressor of ras 1

PDB rendering based on 1kbe.

Available structures: 1kbe, 1kbf

Identifiers

Symbol(s)

KSR1; KSR; RSU2

External IDs

OMIM: 601132 MGI: 105051 HomoloGene: 8410

Gene ontology
Molecular Function:	• protein serine/threonine kinase activity • protein-tyrosine kinase activity • ATP binding • zinc ion binding • diacylglycerol binding • metal ion binding
Cellular Component:	• intracellular • membrane
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade • Ras protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014238 (mRNA)
NP_055053 (protein)

NM_013571 (mRNA)
NP_038599 (protein)

Location

Chr 17: 22.81 - 22.97 Mb

Chr 11: 78.83 - 78.96 Mb

Pubmed search

[1]

[2]

Kinase suppressor of ras 1, also known as KSR1, is a human gene.^[1]

[edit] References

^ Entrez Gene: KSR1 kinase suppressor of ras 1.

[edit] Further reading

Kolesnick R, Xing HR (2004). "Inflammatory bowel disease reveals the kinase activity of KSR1.". J. Clin. Invest. 114 (9): 1233-7. doi:10.1172/JCI200423437. PMID 15520853.
Therrien M, Chang HC, Solomon NM, et al. (1996). "KSR, a novel protein kinase required for RAS signal transduction.". Cell 83 (6): 879-88. PMID 8521512.
Xing HR, Lozano J, Kolesnick R (2000). "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras.". J. Biol. Chem. 275 (23): 17276-80. doi:10.1074/jbc.C900989199. PMID 10764733.
Roy F, Therrien M (2002). "MAP kinase module: the Ksr connection.". Curr. Biol. 12 (9): R325-7. PMID 12007434.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Matheny SA, Chen C, Kortum RL, et al. (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.". Nature 427 (6971): 256-60. doi:10.1038/nature02237. PMID 14724641.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kim M, Yan Y, Kortum RL, et al. (2005). "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity.". Cancer Res. 65 (10): 3986-92. doi:10.1158/0008-5472.CAN-03-2334. PMID 15899786.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045-9. doi:10.1038/nature04689. PMID 16625196.
Wang X, Wang TT, White JH, Studzinski GP (2006). "Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5'-flanking region.". Oncogene 25 (53): 7078-85. doi:10.1038/sj.onc.1209697. PMID 16732322.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.