KRT85

From Wikipedia, the free encyclopedia

Keratin 85

Identifiers

KRT85; HB5; Hb-5; KRTHB5; hHb5

External IDs

OMIM: 602767 MGI: 1859268 HomoloGene: 37603

Gene ontology
Molecular Function:	• structural molecule activity
Cellular Component:	• intermediate filament
Biological Process:	• epidermis development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002283 (mRNA)
NP_002274 (protein)

NM_016879 (mRNA)
NP_058575 (protein)

Location

Chr 12: 51.04 - 51.05 Mb

n/a

Pubmed search

[1]

[2]

Keratin 85, also known as KRT85, is a human gene.^[1]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.^[1]

[edit] References

^ ^a ^b Entrez Gene: KRT85 keratin 85.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Schweizer J, Bowden PE, Coulombe PA, et al. (2006). "New consensus nomenclature for mammalian keratins.". J. Cell Biol. 174 (2): 169-74. doi:10.1083/jcb.200603161. PMID 16831889.
Naeem M, Wajid M, Lee K, et al. (2006). "A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type.". J. Med. Genet. 43 (3): 274-9. doi:10.1136/jmg.2005.033381. PMID 16525032.
Tang K, Finley RL, Nie D, Honn KV (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.". Biochemistry 39 (12): 3185-91. PMID 10727209.
Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.". J. Invest. Dermatol. 114 (3): 464-72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.". J. Biol. Chem. 274 (28): 19874-84. PMID 10391933.
Rogers MA, Langbein L, Praetzel S, et al. (1997). "Sequences and differential expression of three novel human type-II hair keratins.". Differentiation 61 (3): 187-94. PMID 9084137.
Rogers MA, Winter H, Langbein L, et al. (1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5.". J. Invest. Dermatol. 107 (4): 633-8. PMID 8823373.