KREMEN1

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Kringle containing transmembrane protein 1
Identifiers
Symbol(s) KREMEN1; FLJ31863; KREMEM1; KREMEN; KRM1
External IDs OMIM: 609898 MGI: 1933988 HomoloGene: 12935
Orthologs
Human Mouse
Entrez 83999 84035
Ensembl ENSG00000183762 ENSMUSG00000020393
Uniprot Q96MU8 Q640Q6
Refseq NM_001039570 (mRNA)
NP_001034659 (protein)		 NM_032396 (mRNA)
NP_115772 (protein)
Location Chr 22: 27.8 - 27.89 Mb Chr 11: 5.09 - 5.16 Mb
Pubmed search [1] [2]

Kringle containing transmembrane protein 1, also known as KREMEN1, is a human gene.[1]

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: KREMEN1 kringle containing transmembrane protein 1.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mao B, Wu W, Davidson G, et al. (2002). "Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.". Nature 417 (6889): 664-7. doi:10.1038/nature756. PMID 12050670. 
  • Nakamura T, Aoki S, Kitajima K, et al. (2001). "Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein.". Biochim. Biophys. Acta 1518 (1-2): 63-72. PMID 11267660. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208. 
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