KPNA1

From Wikipedia, the free encyclopedia

Karyopherin alpha 1 (importin alpha 5)

PDB rendering based on 2jdq.

Available structures: 2jdq

Identifiers

Symbol(s)

KPNA1; IPOA5; NPI-1; RCH2; SRP1

External IDs

OMIM: 600686 MGI: 103560 HomoloGene: 55642

Gene ontology
Molecular Function:	• protein binding • nuclear localization sequence binding • protein transporter activity
Cellular Component:	• nucleus • nuclear pore • cytoplasm
Biological Process:	• regulation of DNA recombination • NLS-bearing substrate import into nucleus • intracellular protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002264 (mRNA)
NP_002255 (protein)

NM_008465 (mRNA)
NP_032491 (protein)

Location

Chr 3: 123.63 - 123.72 Mb

Chr 16: 35.9 - 35.96 Mb

Pubmed search

[1]

[2]

Karyopherin alpha 1 (importin alpha 5), also known as KPNA1, is a human gene.

Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination^[1]

[edit] References

^ Entrez Gene: KPNA1 karyopherin alpha 1 (importin alpha 5).

[edit] Further reading

Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader.". Front. Biosci. 2: d578–87. PMID 9366553.
Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.". Mol. Med. 4 (3): 138–43. PMID 9562972.
Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. PMID 1631159.
Sharova N, Bukrinskaya A (1991). "p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.". AIDS Res. Hum. Retroviruses 7 (3): 303–6. PMID 2064827.
Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.". J. Virol. 69 (12): 7909–16. PMID 7494303.
Gallay P, Swingler S, Song J, et al. (1995). "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.". Cell 83 (4): 569–76. PMID 7585960.
Moroianu J, Hijikata M, Blobel G, Radu A (1995). "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. PMID 7604027.
Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.". J. Virol. 69 (6): 3949–54. PMID 7745752.
Weis K, Mattaj IW, Lamond AI (1995). "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences.". Science 268 (5213): 1049–53. PMID 7754385.
O'Neill RE, Palese P (1995). "NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein.". Virology 206 (1): 116–25. PMID 7831767.
Gallay P, Swingler S, Aiken C, Trono D (1995). "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.". Cell 80 (3): 379–88. PMID 7859280.
Moroianu J, Blobel G, Radu A (1995). "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2008–11. PMID 7892216.
von Schwedler U, Kornbluth RS, Trono D (1994). "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. PMID 8041734.
Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. PMID 8041786.
Cortes P, Ye ZS, Baltimore D (1994). "RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.". Proc. Natl. Acad. Sci. U.S.A. 91 (16): 7633–7. PMID 8052633.
Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.". Nature 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.
Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.". Mol. Med. 1 (2): 217–30. PMID 8529100.
Gallay P, Stitt V, Mundy C, et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.". J. Virol. 70 (2): 1027–32. PMID 8551560.
Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. PMID 8552640.