KLRK1

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Killer cell lectin-like receptor subfamily K, member 1
PDB rendering based on 1hyr.
Available structures: 1hyr, 1kcg, 1mpu
Identifiers
Symbol(s) KLRK1; CD314; D12S2489E; KLR; NKG2-D; NKG2D
External IDs MGI: 1196250 HomoloGene: 7209
Orthologs
Human Mouse
Entrez 22914 27007
Ensembl n/a ENSMUSG00000030149
Uniprot n/a Q2TJJ6
Refseq NM_007360 (mRNA)
NP_031386 (protein)		 XM_001004553 (mRNA)
XP_001004553 (protein)
Location n/a Chr 6: 129.58 - 129.59 Mb
Pubmed search [1] [2]

Killer cell lectin-like receptor subfamily K, member 1, also known as KLRK1, is a human gene. KLRK1 has also been designated as CD314 (cluster of differentiation 314).

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. D12S2489E is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The first non-coding exon at the 5' end of the D12S2489E transcript is included in the 3' end of the KLRC4 transcript.[1]

[edit] References

  1. ^ Entrez Gene: KLRK1 killer cell lectin-like receptor subfamily K, member 1.

[edit] Further reading

  • Raulet DH (2003). "Roles of the NKG2D immunoreceptor and its ligands.". Nat. Rev. Immunol. 3 (10): 781–90. doi:10.1038/nri1199. PMID 14523385. 
  • Lanier LL (2004). "NKG2D.". J. Biol. Regul. Homeost. Agents 17 (4): 338–40. PMID 15065764. 
  • Coudert JD, Held W (2006). "The role of the NKG2D receptor for tumor immunity.". Semin. Cancer Biol. 16 (5): 333–43. doi:10.1016/j.semcancer.2006.07.008. PMID 16914326. 
  • Houchins JP, Yabe T, McSherry C, Bach FH (1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.". J. Exp. Med. 173 (4): 1017–20. PMID 2007850. 
  • Spertini O, Frei PC (1986). "Biophysical properties and morphology of purified antigen associated with non-A, non-B hepatitis.". Med. Microbiol. Immunol. 175 (4): 229–39. PMID 2426565. 
  • Plougastel B, Trowsdale J (1998). "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.". Eur. J. Immunol. 27 (11): 2835–9. PMID 9394807. 
  • Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306. 
  • Glienke J, Sobanov Y, Brostjan C, et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.". Immunogenetics 48 (3): 163–73. PMID 9683661. 
  • Li P, Willie ST, Bauer S, et al. (1999). "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand.". Immunity 10 (5): 577–84. PMID 10367903. 
  • Bauer S, Groh V, Wu J, et al. (1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.". Science 285 (5428): 727–9. PMID 10426993. 
  • Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730–2. PMID 10426994. 
  • Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123–33. PMID 11239445. 
  • Diefenbach A, Jamieson AM, Liu SD, et al. (2001). "Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.". Nat. Immunol. 1 (2): 119–26. doi:10.1038/77793. PMID 11248803. 
  • Li P, Morris DL, Willcox BE, et al. (2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.". Nat. Immunol. 2 (5): 443–51. doi:10.1038/87757. PMID 11323699. 
  • Shum BP, Flodin LR, Muir DG, et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.". J. Immunol. 168 (1): 240–52. PMID 11751968. 
  • Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.". Immunity 15 (6): 1039–49. PMID 11754823. 
  • Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671–9. PMID 11777960. 
  • Holmes MA, Li P, Petersdorf EW, Strong RK (2002). "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.". J. Immunol. 169 (3): 1395–400. PMID 12133964. 
  • Groh V, Wu J, Yee C, Spies T (2002). "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.". Nature 419 (6908): 734–8. doi:10.1038/nature01112. PMID 12384702. 
  • Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. 

[edit] External links


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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350