KLRG1

From Wikipedia, the free encyclopedia

Killer cell lectin-like receptor subfamily G, member 1

Identifiers

KLRG1; 2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MGC13600

External IDs

OMIM: 604874 MGI: 1355294 HomoloGene: 4244

Gene ontology
Molecular Function:	• receptor activity • sugar binding
Cellular Component:	• integral to membrane
Biological Process:	• inflammatory response • cellular defense response • cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005810 (mRNA)
NP_005801 (protein)

NM_016970 (mRNA)
NP_058666 (protein)

Location

Chr 12: 9.03 - 9.05 Mb

Chr 6: 122.24 - 122.25 Mb

Pubmed search

[1]

[2]

Killer cell lectin-like receptor subfamily G, member 1, also known as KLRG1, is a human gene.^[1]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: KLRG1 killer cell lectin-like receptor subfamily G, member 1.

[edit] Further reading

Ortega E, Schneider H, Pecht I (1991). "Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen.". Int. Immunol. 3 (4): 333–42. PMID 1831652.
Lamers MB, Lamont AG, Williams DH (1998). "Human MAFA has alternatively spliced variants.". Biochim. Biophys. Acta 1399 (2-3): 209–12. PMID 9765598.
Butcher S, Arney KL, Cook GP (1998). "MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells.". Eur. J. Immunol. 28 (11): 3755–62. PMID 9842918.
Hanke T, Corral L, Vance RE, Raulet DH (1999). "2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells.". Eur. J. Immunol. 28 (12): 4409–17. PMID 9862378.
Voehringer D, Koschella M, Pircher H (2003). "Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1).". Blood 100 (10): 3698–702. doi:10.1182/blood-2002-02-0657. PMID 12393723.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuoka TA, Artner I, Henderson E, et al. (2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930–3. doi:10.1073/pnas.0306233101. PMID 14973194.
Marcolino I, Przybylski GK, Koschella M, et al. (2004). "Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history.". Eur. J. Immunol. 34 (10): 2672–80. doi:10.1002/eji.200425282. PMID 15368283.
Ibegbu CC, Xu YX, Harris W, et al. (2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57.". J. Immunol. 174 (10): 6088–94. PMID 15879103.
Thimme R, Appay V, Koschella M, et al. (2005). "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.". J. Virol. 79 (18): 12112–6. doi:10.1128/JVI.79.18.12112-12116.2005. PMID 16140789.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ito M, Maruyama T, Saito N, et al. (2006). "Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity.". J. Exp. Med. 203 (2): 289–95. doi:10.1084/jem.20051986. PMID 16461340.
Bengsch B, Spangenberg HC, Kersting N, et al. (2007). "Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.". J. Virol. 81 (2): 945–53. doi:10.1128/JVI.01354-06. PMID 17079288.
Schwartzkopff S, Gründemann C, Schweier O, et al. (2007). "Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans.". J. Immunol. 179 (2): 1022–9. PMID 17617594.