KLRC2
From Wikipedia, the free encyclopedia
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Killer cell lectin-like receptor subfamily C, member 2
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| Identifiers | ||||||||||||||
| Symbol(s) | KLRC2; CD159c; MGC138244; NKG2-C; NKG2C | |||||||||||||
| External IDs | OMIM: 602891 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3822 | n/a | ||||||||||||
| Ensembl | ENSG00000205809 | n/a | ||||||||||||
| Uniprot | P26717 | n/a | ||||||||||||
| Refseq | NM_002260 (mRNA) NP_002251 (protein) |
n/a (mRNA) n/a (protein) |
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| Location | Chr 12: 10.47 - 10.48 Mb | n/a | ||||||||||||
| Pubmed search | [1] | n/a | ||||||||||||
Killer cell lectin-like receptor subfamily C, member 2, also known as KLRC2, is a human gene.[1]
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.[1]
[edit] See also
[edit] References
[edit] Further reading
- Houchins JP, Yabe T, McSherry C, Bach FH (1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.". J. Exp. Med. 173 (4): 1017-20. PMID 2007850.
- Yabe T, McSherry C, Bach FH, et al. (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins.". Immunogenetics 37 (6): 455-60. PMID 8436421.
- Houchins JP, Lanier LL, Niemi EC, et al. (1997). "Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.". J. Immunol. 158 (8): 3603-9. PMID 9103421.
- Braud VM, Allan DS, O'Callaghan CA, et al. (1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.". Nature 391 (6669): 795-9. doi:. PMID 9486650.
- Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.". Genomics 49 (2): 193-9. doi:. PMID 9598306.
- Lanier LL, Corliss B, Wu J, Phillips JH (1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors.". Immunity 8 (6): 693-701. PMID 9655483.
- Glienke J, Sobanov Y, Brostjan C, et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex.". Immunogenetics 48 (3): 163-73. PMID 9683661.
- Ding Y, Sumitran S, Holgersson J (1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells.". Scand. J. Immunol. 49 (5): 459-65. PMID 10320637.
- Khakoo SI, Rajalingam R, Shum BP, et al. (2000). "Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans.". Immunity 12 (6): 687-98. PMID 10894168.
- Shum BP, Flodin LR, Muir DG, et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.". J. Immunol. 168 (1): 240-52. PMID 11751968.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:. PMID 12477932.
- Hikami K, Tsuchiya N, Yabe T, Tokunaga K (2003). "Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population.". Genes Immun. 4 (2): 160-7. doi:. PMID 12618865.
- Miyashita R, Tsuchiya N, Hikami K, et al. (2004). "Molecular genetic analyses of human NKG2C (KLRC2) gene deletion.". Int. Immunol. 16 (1): 163-8. PMID 14688071.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:. PMID 15489334.
- Ortega C, Romero P, Palma A, et al. (2005). "Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses.". Immunol. Cell Biol. 82 (6): 587-95. doi:. PMID 15550116.
- Gumá M, Busch LK, Salazar-Fontana LI, et al. (2005). "The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.". Eur. J. Immunol. 35 (7): 2071-80. doi:. PMID 15940674.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
