KLK10

From Wikipedia, the free encyclopedia

Kallikrein-related peptidase 10

Identifiers

KLK10; NES1; PRSSL1

External IDs

OMIM: 602673 MGI: 1916790 HomoloGene: 26428

Gene ontology
Molecular Function:	• serine-type endopeptidase activity
Cellular Component:	• extracellular region
Biological Process:	• proteolysis • cell cycle • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001077500 (mRNA)
NP_001070968 (protein)

NM_133712 (mRNA)
NP_598473 (protein)

Location

Chr 19: 56.21 - 56.22 Mb

Chr 7: 43.65 - 43.65 Mb

Pubmed search

[1]

[2]

Kallikrein-related peptidase 10, also known as KLK10, is a human gene.^[1]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: KLK10 kallikrein-related peptidase 10.

[edit] Further reading

Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis.". Trends Endocrinol. Metab. 11 (2): 54-60. PMID 10675891.
Zhang Y, Bhat I, Zeng M, et al. (2006). "Human kallikrein 10, a predictive marker for breast cancer.". Biol. Chem. 387 (6): 715-21. doi:10.1515/BC.2006.090. PMID 16800732.
Liu XL, Wazer DE, Watanabe K, Band V (1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression.". Cancer Res. 56 (14): 3371-9. PMID 8764136.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Polikoff D, Kuo WL, Cochran JF, et al. (1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping.". Cytogenet. Cell Genet. 79 (1-2): 147-8. PMID 9533035.
Luo L, Herbrick JA, Scherer SW, et al. (1998). "Structural characterization and mapping of the normal epithelial cell-specific 1 gene.". Biochem. Biophys. Res. Commun. 247 (3): 580-6. doi:10.1006/bbrc.1998.8793. PMID 9647736.
Goyal J, Smith KM, Cowan JM, et al. (1998). "The role for NES1 serine protease as a novel tumor suppressor.". Cancer Res. 58 (21): 4782-6. PMID 9809976.
Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.". J. Biol. Chem. 275 (48): 37397-406. doi:10.1074/jbc.M004525200. PMID 10969073.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.". Gene 257 (1): 119-30. PMID 11054574.
Dhar S, Bhargava R, Yunes M, et al. (2002). "Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer.". Clin. Cancer Res. 7 (11): 3393-8. PMID 11705853.
Bharaj BB, Luo LY, Jung K, et al. (2002). "Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers.". Prostate 51 (1): 35-41. PMID 11920956.
Luo LY, Diamandis EP, Look MP, et al. (2002). "Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance.". Br. J. Cancer 86 (11): 1790-6. doi:10.1038/sj.bjc.6600323. PMID 12087468.
Petraki CD, Karavana VN, Luo LY, Diamandis EP (2002). "Human kallikrein 10 expression in normal tissues by immunohistochemistry.". J. Histochem. Cytochem. 50 (9): 1247-61. PMID 12185203.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Petraki CD, Gregorakis AK, Papanastasiou PA, et al. (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues.". Prostate Cancer Prostatic Dis. 6 (3): 223-7. doi:10.1038/sj.pcan.4500674. PMID 12970725.
Sauter ER, Lininger J, Magklara A, et al. (2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk.". Int. J. Cancer 108 (4): 588-91. doi:10.1002/ijc.11607. PMID 14696124.
Diamandis EP, Scorilas A, Kishi T, et al. (2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.". Clin. Biochem. 37 (3): 230-7. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.