KLHDC3

From Wikipedia, the free encyclopedia

Kelch domain containing 3

Identifiers

KLHDC3; PEAS; RP1-20C7.3; dJ20C7.3; hPeas

External IDs

Gene ontology
Molecular Function:	• chromatin binding
Cellular Component:	• nuclear chromatin • cytoplasm
Biological Process:	• meiotic recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_057161 (mRNA)
NP_476502 (protein)

NM_027910 (mRNA)
NP_082186 (protein)

Location

Chr 6: 43.09 - 43.1 Mb

Chr 17: 46.14 - 46.14 Mb

Pubmed search

[1]

[2]

Kelch domain containing 3, also known as KLHDC3, is a human gene.^[1]

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.^[1]

[edit] References

^ ^a ^b Entrez Gene: KLHDC3 kelch domain containing 3.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ohinata Y, Sutou S, Mitsui Y (2003). "Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals.". DNA Res. 10 (2): 79–84. PMID 12755172.
Ohinata Y, Sutou S, Mitsui Y (2003). "A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin.". FEBS Lett. 537 (1-3): 1–5. PMID 12606021.
Hermey G, Keat SJ, Madsen P, et al. (2003). "Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.". J. Biol. Chem. 278 (9): 7390–6. doi:10.1074/jbc.M210851200. PMID 12482870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ohinata Y, Sutou S, Kondo M, et al. (2003). "Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis.". Biol. Reprod. 67 (6): 1824–31. PMID 12444059.