KLF5

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Kruppel-like factor 5 (intestinal)
Identifiers
Symbol(s) KLF5; BTEB2; CKLF; IKLF
External IDs OMIM: 602903 MGI: 1338056 HomoloGene: 37520
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 688 12224
Ensembl ENSG00000102554 ENSMUSG00000005148
Uniprot Q13887 Q923C0
Refseq NM_001730 (mRNA)
NP_001721 (protein)		 NM_009769 (mRNA)
NP_033899 (protein)
Location Chr 13: 72.53 - 72.55 Mb Chr 14: 98.18 - 98.2 Mb
Pubmed search [1] [2]

Kruppel-like factor 5 (intestinal), also known as KLF5, is a human gene.[1]

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal).

[edit] Further reading

  • Ghaleb AM, Nandan MO, Chanchevalap S, et al. (2005). "Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation.". Cell Res. 15 (2): 92–6. doi:10.1038/sj.cr.7290271. PMID 15740636. 
  • Nagai R, Suzuki T, Aizawa K, et al. (2005). "Significance of the transcription factor KLF5 in cardiovascular remodeling.". J. Thromb. Haemost. 3 (8): 1569–76. doi:10.1111/j.1538-7836.2005.01366.x. PMID 16102021. 
  • McConnell BB, Ghaleb AM, Nandan MO, Yang VW (2007). "The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology.". Bioessays 29 (6): 549–57. doi:10.1002/bies.20581. PMID 17508399. 
  • Sogawa K, Imataka H, Yamasaki Y, et al. (1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.". Nucleic Acids Res. 21 (7): 1527–32. PMID 8479902. 
  • Kojima S, Kobayashi A, Gotoh O, et al. (1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor.". J. Biochem. 121 (2): 389–96. PMID 9089417. 
  • Conkright MD, Wani MA, Anderson KP, Lingrel JB (1999). "A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells.". Nucleic Acids Res. 27 (5): 1263–70. PMID 9973612. 
  • Shi H, Zhang Z, Wang X, et al. (2000). "Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.". Nucleic Acids Res. 27 (24): 4807–15. PMID 10572182. 
  • Hoshino Y, Kurabayashi M, Kanda T, et al. (2000). "Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis.". Circulation 102 (20): 2528–34. PMID 11076828. 
  • Sun R, Chen X, Yang VW (2001). "Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation.". J. Biol. Chem. 276 (10): 6897–900. doi:10.1074/jbc.C000870200. PMID 11152667. 
  • Dang DT, Zhao W, Mahatan CS, et al. (2002). "Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene.". Nucleic Acids Res. 30 (13): 2736–41. PMID 12087155. 
  • Shindo T, Manabe I, Fukushima Y, et al. (2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.". Nat. Med. 8 (8): 856–63. doi:10.1038/nm738. PMID 12101409. 
  • Sur I, Undén AB, Toftgård R (2003). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles.". Eur. J. Cell Biol. 81 (6): 323–34. PMID 12113473. 
  • Chen C, Bhalala HV, Qiao H, Dong JT (2002). "A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer.". Oncogene 21 (43): 6567–72. doi:10.1038/sj.onc.1205817. PMID 12242654. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yang XO, Doty RT, Hicks JS, Willerford DM (2003). "Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs.". Blood 101 (11): 4492–9. doi:10.1182/blood-2002-08-2579. PMID 12576331. 
  • Chen C, Bhalala HV, Vessella RL, Dong JT (2003). "KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer.". Prostate 55 (2): 81–8. doi:10.1002/pros.10205. PMID 12661032. 
  • Zhang Z, Teng CT (2003). "Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.". Nucleic Acids Res. 31 (8): 2196–208. PMID 12682370. 
  • Ohnishi S, Ohnami S, Laub F, et al. (2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer.". Biochem. Biophys. Res. Commun. 308 (2): 251–6. PMID 12901861. 
  • Aizawa K, Suzuki T, Kada N, et al. (2004). "Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB.". J. Biol. Chem. 279 (1): 70–6. doi:10.1074/jbc.M306621200. PMID 14573617. 
  • Sato T, Kanda T, Iida T, et al. (2004). "Immunohistochemical study of surgically excised choroidal neovascular membranes.". J. Int. Med. Res. 31 (5): 402–6. PMID 14587307. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD