KLF3

From Wikipedia, the free encyclopedia

Kruppel-like factor 3 (basic)

PDB rendering based on 1p7a.

Available structures: 1p7a, 1u85, 1u86

Identifiers

Symbol(s)

KLF3; BKLF; MGC48279

External IDs

OMIM: 609392 MGI: 1342773 HomoloGene: 7396

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016531 (mRNA)
NP_057615 (protein)

XM_994052 (mRNA)
XP_999146 (protein)

Location

Chr 4: 38.34 - 38.38 Mb

Chr 5: 65.08 - 65.11 Mb

Pubmed search

[1]

[2]

Kruppel-like factor 3 (basic), also known as KLF3, is a human gene.^[1]

[edit] References

^ Entrez Gene: KLF3 Kruppel-like factor 3 (basic).

[edit] Further reading

Turner J, Crossley M (2000). "Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors.". Int. J. Biochem. Cell Biol. 31 (10): 1169–74. PMID 10582345.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMID 9724649.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang MJ, Qu XH, Wang LS, et al. (2003). "[cDNA cloning, subcellular localization and tissue expression of a new human Krüppel-like transcription factor: human basic Krüppel-like factor (hBKLF)]". Yi Chuan Xue Bao 30 (1): 1–9. PMID 12812068.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Perdomo J, Verger A, Turner J, Crossley M (2005). "Role for SUMO modification in facilitating transcriptional repression by BKLF.". Mol. Cell. Biol. 25 (4): 1549–59. doi:10.1128/MCB.25.4.1549-1559.2005. PMID 15684403.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.