KLC3

From Wikipedia, the free encyclopedia

Kinesin light chain 3

Identifiers

KLC3; KLC2; KLC2L; KLCt; KNS2B

External IDs

OMIM: 601334 MGI: 1277971 HomoloGene: 14899

Gene ontology
Molecular Function:	• microtubule motor activity • protein binding • microtubule binding • cardiolipin synthase activity • kinesin binding
Cellular Component:	• cytoplasm • kinesin complex • microtubule • microtubule-based flagellum • ciliary rootlet • neuron projection

Orthologs

Human

Mouse

Refseq

NM_177417 (mRNA)
NP_803136 (protein)

NM_146182 (mRNA)
NP_666294 (protein)

Location

Chr 19: 50.54 - 50.55 Mb

Chr 7: 18.55 - 18.56 Mb

Pubmed search

[1]

[2]

Kinesin light chain 3, also known as KLC3, is a human gene.^[1]

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.^[1]

[edit] References

^ ^a ^b Entrez Gene: KLC3 kinesin light chain 3.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang Y, Oko R, van der Hoorn FA (2004). "Rat kinesin light chain 3 associates with spermatid mitochondria.". Dev. Biol. 275 (1): 23-33. doi:10.1016/j.ydbio.2004.07.014. PMID 15464570.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436-50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Bhullar B, Zhang Y, Junco A, et al. (2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.". J. Biol. Chem. 278 (18): 16159-68. doi:10.1074/jbc.M213126200. PMID 12594206.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yang J, Liu X, Yue G, et al. (2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet.". J. Cell Biol. 159 (3): 431-40. doi:10.1083/jcb.200207153. PMID 12427867.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C, et al. (2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.". Biochemistry 41 (17): 5566-72. PMID 11969417.
Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids.". Biol. Reprod. 64 (5): 1320-30. PMID 11319135.
Rahman A, Kamal A, Roberts EA, Goldstein LS (1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants.". J. Cell Biol. 146 (6): 1277-88. PMID 10491391.
Rahman A, Friedman DS, Goldstein LS (1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins.". J. Biol. Chem. 273 (25): 15395-403. PMID 9624122.
Lamerdin JE, Stilwagen SA, Ramirez MH, et al. (1996). "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes.". Genomics 34 (3): 399-409. doi:10.1006/geno.1996.0303. PMID 8786141.