KiSS1-derived peptide receptor

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KISS1 receptor
Identifiers
Symbol(s) KISS1R; AXOR12; GPR54; HOT7T175
External IDs OMIM: 604161 MGI: 2148793 HomoloGene: 11411
Orthologs
Human Mouse
Entrez 84634 114229
Ensembl ENSG00000116014 ENSMUSG00000035773
Uniprot Q969F8 Q91V45
Refseq NM_032551 (mRNA)
NP_115940 (protein)		 NM_053244 (mRNA)
NP_444474 (protein)
Location Chr 19: 0.87 - 0.87 Mb Chr 10: 79.32 - 79.33 Mb
Pubmed search [1] [2]

The KiSS1-derived peptide receptor (also known as GPR54) is a G protein-coupled receptor[1] which binds the peptide hormone kisspeptin.[2][3][4]

The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty.[5]

[edit] References

  1. ^ Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF (1999). "Discovery of a receptor related to the galanin receptors". FEBS Lett. 446 (1): 103–7. PMID 10100623. 
  2. ^ Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M (2001). "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor". Nature 411 (6837): 613–7. doi:10.1038/35079135. PMID 11385580. 
  3. ^ Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC (2001). "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1". J. Biol. Chem. 276 (31): 28969–75. doi:10.1074/jbc.M102743200. PMID 11387329. 
  4. ^ Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M (2001). "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54". J. Biol. Chem. 276 (37): 34631–6. doi:10.1074/jbc.M104847200. PMID 11457843. 
  5. ^ Entrez Gene: KISS1R KISS1 receptor.

[edit] Further reading

  • Colledge WH (2005). "GPR54 and puberty.". Trends Endocrinol. Metab. 15 (9): 448–53. doi:10.1016/j.tem.2004.09.008. PMID 15519892. 
  • Kaiser UB, Kuohung W (2006). "KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty.". Endocrine 26 (3): 277–84. PMID 16034182. 
  • Seminara SB (2006). "Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion.". Frontiers in neuroendocrinology 26 (3-4): 131–8. doi:10.1016/j.yfrne.2005.10.001. PMID 16309735. 
  • Tena-Sempere M (2006). "GPR54 and kisspeptin in reproduction.". Hum. Reprod. Update 12 (5): 631–9. doi:10.1093/humupd/dml023. PMID 16731583. 
  • Cerrato F, Seminara SB (2007). "Human genetics of GPR54.". Reviews in endocrine & metabolic disorders 8 (1): 47–55. doi:10.1007/s11154-007-9027-3. PMID 17334928. 
  • Lee DK, Nguyen T, O'Neill GP, et al. (1999). "Discovery of a receptor related to the galanin receptors.". FEBS Lett. 446 (1): 103–7. PMID 10100623. 
  • Ohtaki T, Shintani Y, Honda S, et al. (2001). "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.". Nature 411 (6837): 613–7. doi:10.1038/35079135. PMID 11385580. 
  • Muir AI, Chamberlain L, Elshourbagy NA, et al. (2001). "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.". J. Biol. Chem. 276 (31): 28969–75. doi:10.1074/jbc.M102743200. PMID 11387329. 
  • Clements MK, McDonald TP, Wang R, et al. (2001). "FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54.". Biochem. Biophys. Res. Commun. 284 (5): 1189–93. doi:10.1006/bbrc.2001.5098. PMID 11414709. 
  • Kotani M, Detheux M, Vandenbogaerde A, et al. (2001). "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.". J. Biol. Chem. 276 (37): 34631–6. doi:10.1074/jbc.M104847200. PMID 11457843. 
  • Hori A, Honda S, Asada M, et al. (2001). "Metastin suppresses the motility and growth of CHO cells transfected with its receptor.". Biochem. Biophys. Res. Commun. 286 (5): 958–63. doi:10.1006/bbrc.2001.5470. PMID 11527393. 
  • Ringel MD, Hardy E, Bernet VJ, et al. (2002). "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.". J. Clin. Endocrinol. Metab. 87 (5): 2399. PMID 11994395. 
  • Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. PMID 12414911. 
  • Bo-Abbas Y, Acierno JS, Shagoury JK, et al. (2003). "Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes.". J. Clin. Endocrinol. Metab. 88 (6): 2730–7. PMID 12788881. 
  • Ikeguchi M, Hirooka Y, Kaibara N (2003). "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma.". J. Cancer Res. Clin. Oncol. 129 (9): 531–5. doi:10.1007/s00432-003-0469-z. PMID 12898236. 
  • de Roux N, Genin E, Carel JC, et al. (2003). "Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54.". Proc. Natl. Acad. Sci. U.S.A. 100 (19): 10972–6. doi:10.1073/pnas.1834399100. PMID 12944565. 
  • Seminara SB, Messager S, Chatzidaki EE, et al. (2003). "The GPR54 gene as a regulator of puberty.". N. Engl. J. Med. 349 (17): 1614–27. doi:10.1056/NEJMoa035322. PMID 14573733. 
  • Ikeguchi M, Yamaguchi K, Kaibara N (2004). "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma.". Clin. Cancer Res. 10 (4): 1379–83. PMID 14977840. 
  • Bilban M, Ghaffari-Tabrizi N, Hintermann E, et al. (2004). "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.". J. Cell. Sci. 117 (Pt 8): 1319–28. doi:10.1242/jcs.00971. PMID 15020672. 
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. 

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v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened
Languages