Kinesin 8
From Wikipedia, the free encyclopedia
The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesins. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP-hydrolysis-created energy. The Kinesin 8 family has been shown to play an important role in chromosome alignment during mitosis. Kinesin 8 family members KIF18A in humans[1] and Kip3 in yeast[2] have been shown to be in vivo plus-end directed microtubule depolymerizers. During prometaphase of mitosis, the microtubules attach to the kinetochores of sister chromatids. Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister chromatids that are unable to align properly (see External Links).[1][3]
[edit] References
- ^ a b Mayr, M.I., Hummer, S., Bormann, J., Gruner, T., Adio, S., Woehlke, G., and T. U. Mayer (2007) Current Biology 17: 488-498.
- ^ Gupta, M.L., Jr., Carvalho, P., Roof, D.M., and D. Pellman (2006) Nature. Cell Biology 8: 913-923.
- ^ Stumpff, J., Dassow, G.V., Wagenbach, M., Asbury, C., and L. Wordeman (2008) Developmental Cell 14(2): 252-262.
