KIF4A

From Wikipedia, the free encyclopedia

Kinesin family member 4A

Identifiers

KIF4A; FLJ12530; FLJ12655; FLJ14204; FLJ20631; HSA271784; KIF4; KIF4-G1

External IDs

OMIM: 300521 MGI: 108389 HomoloGene: 69022

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • microtubule motor activity • ATP binding
Cellular Component:	• nucleus • cytoplasm • microtubule associated complex • spindle microtubule
Biological Process:	• organelle organization and biogenesis • microtubule-based movement • anterograde axon cargo transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012310 (mRNA)
NP_036442 (protein)

XM_982929 (mRNA)
XP_988023 (protein)

Location

Chr X: 69.43 - 69.56 Mb

Chr X: 96.83 - 96.93 Mb

Pubmed search

[1]

[2]

Kinesin family member 4A, also known as KIF4A, is a human gene.^[1]

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division (Zhu and Jiang, 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: KIF4A kinesin family member 4A.

[edit] Further reading

Sekine Y, Okada Y, Noda Y, et al. (1994). "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.". J. Cell Biol. 127 (1): 187–201. PMID 7929562.
Yan RT, Wang SZ (1997). "Increased chromokinesin immunoreactivity in retinoblastoma cells.". Gene 189 (2): 263–7. PMID 9168136.
Tang Y, Winkler U, Freed EO, et al. (1999). "Cellular motor protein KIF-4 associates with retroviral Gag.". J. Virol. 73 (12): 10508–13. PMID 10559369.
Ha MJ, Yoon J, Moon E, et al. (2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.". Cytogenet. Cell Genet. 88 (1-2): 41–2. PMID 10773663.
Oh S, Hahn H, Torrey TA, et al. (2000). "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.". Biochim. Biophys. Acta 1493 (1-2): 219–24. PMID 10978527.
Lee YM, Lee S, Lee E, et al. (2002). "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis.". Biochem. J. 360 (Pt 3): 549–56. PMID 11736643.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee YM, Kim W (2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35.". Biochem. J. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMID 12809554.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.". Biochem. Biophys. Res. Commun. 308 (4): 793–801. PMID 12927788.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lee YM, Kim W (2004). "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells.". Exp. Mol. Med. 36 (1): 93–7. PMID 15031677.
Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMID 15148359.
Kurasawa Y, Earnshaw WC, Mochizuki Y, et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMID 15297875.
Mazumdar M, Sundareshan S, Misteli T (2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation.". J. Cell Biol. 166 (5): 613–20. doi:10.1083/jcb.200401142. PMID 15326200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhu C, Jiang W (2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis.". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 343–8. doi:10.1073/pnas.0408438102. PMID 15625105.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.