KIF3B

From Wikipedia, the free encyclopedia

Kinesin family member 3B

Identifiers

KIF3B; HH0048; KIAA0359

External IDs

OMIM: 603754 MGI: 107688 HomoloGene: 55849

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • plus-end-directed microtubule motor activity
Cellular Component:	• plus-end kinesin complex • microtubule • microtubule associated complex
Biological Process:	• microtubule-based movement • determination of left/right symmetry • anterograde axon cargo transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004798 (mRNA)
NP_004789 (protein)

NM_008444 (mRNA)
NP_032470 (protein)

Location

Chr 20: 30.33 - 30.39 Mb

Chr 2: 152.98 - 153.02 Mb

Pubmed search

[1]

[2]

Kinesin family member 3B, also known as KIF3B, is a human gene.^[1]

The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily.^[1]

[edit] References

^ ^a ^b Entrez Gene: KIF3B kinesin family member 3B.

[edit] Further reading

Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.". J. Cell Biol. 130 (6): 1387–99. PMID 7559760.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMID 9427749.
Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.". J. Biol. Chem. 273 (12): 6591–4. PMID 9506951.
Nonaka S, Tanaka Y, Okada Y, et al. (1999). "Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.". Cell 95 (6): 829–37. PMID 9865700.
Navarro E, Espinosa L, Adell T, et al. (1999). "Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements.". Biochim. Biophys. Acta 1450 (3): 254–64. PMID 10395937.
Whitehead JL, Wang SY, Bost-Usinger L, et al. (1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina.". Exp. Eye Res. 69 (5): 491–503. doi:10.1006/exer.1999.0724. PMID 10548469.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Jimbo T, Kawasaki Y, Koyama R, et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily.". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492.
Baker SA, Freeman K, Luby-Phelps K, et al. (2003). "IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia.". J. Biol. Chem. 278 (36): 34211–8. doi:10.1074/jbc.M300156200. PMID 12821668.
Imamura T, Huang J, Usui I, et al. (2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.". Mol. Cell. Biol. 23 (14): 4892–900. PMID 12832475.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Zhang Y, Hancock WO (2005). "The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds.". Biophys. J. 87 (3): 1795–804. doi:10.1529/biophysj.104.039842. PMID 15345558.
Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis.". J. Biol. Chem. 281 (7): 4094–9. doi:10.1074/jbc.M507028200. PMID 16298999.
Wu Y, Dai XQ, Li Q, et al. (2006). "Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.". Hum. Mol. Genet. 15 (22): 3280–92. doi:10.1093/hmg/ddl404. PMID 17008358.