KIF3A

From Wikipedia, the free encyclopedia

Kinesin family member 3A

Identifiers

External IDs

OMIM: 604683 MGI: 107689 HomoloGene: 38266

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • protein binding • ATP binding
Cellular Component:	• microtubule • microtubule associated complex
Biological Process:	• kidney development • organelle organization and biogenesis • microtubule-based movement • determination of left/right symmetry • dorsal/ventral pattern formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007054 (mRNA)
NP_008985 (protein)

NM_008443 (mRNA)
NP_032469 (protein)

Location

Chr 5: 132.06 - 132.1 Mb

Chr 11: 53.41 - 53.45 Mb

Pubmed search

[1]

[2]

Kinesin family member 3A, also known as KIF3A, is a human gene.^[1]

[edit] References

^ Entrez Gene: KIF3A kinesin family member 3A.

[edit] Further reading

Aizawa H, Sekine Y, Takemura R, et al. (1992). "Kinesin family in murine central nervous system.". J. Cell Biol. 119 (5): 1287-96. PMID 1447303.
Yamazaki H, Nakata T, Okada Y, Hirokawa N (1995). "KIF3A/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport.". J. Cell Biol. 130 (6): 1387-99. PMID 7559760.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.". EMBO J. 17 (1): 149-58. doi:10.1093/emboj/17.1.149. PMID 9427749.
Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse.". Mol. Biol. Cell 9 (2): 249-61. PMID 9450952.
Shimizu K, Shirataki H, Honda T, et al. (1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.". J. Biol. Chem. 273 (12): 6591-4. PMID 9506951.
Whitehead JL, Wang SY, Bost-Usinger L, et al. (1999). "Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina.". Exp. Eye Res. 69 (5): 491-503. doi:10.1006/exer.1999.0724. PMID 10548469.
Hasegawa T, Yagi A, Isobe K (2000). "Interaction between GADD34 and kinesin superfamily, KIF3A.". Biochem. Biophys. Res. Commun. 267 (2): 593-6. doi:10.1006/bbrc.1999.1991. PMID 10631107.
Jimbo T, Kawasaki Y, Koyama R, et al. (2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily.". Nat. Cell Biol. 4 (4): 323-7. doi:10.1038/ncb779. PMID 11912492.
Aronov S, Aranda G, Behar L, Ginzburg I (2003). "Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules.". J. Cell. Sci. 115 (Pt 19): 3817-27. PMID 12235292.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369-76. doi:10.1021/bi034575v. PMID 14690447.
Zhang Y, Hancock WO (2005). "The two motor domains of KIF3A/B coordinate for processive motility and move at different speeds.". Biophys. J. 87 (3): 1795-804. doi:10.1529/biophysj.104.039842. PMID 15345558.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268-74. doi:10.1038/nature02919. PMID 15372022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Brown CL, Maier KC, Stauber T, et al. (2006). "Kinesin-2 is a motor for late endosomes and lysosomes.". Traffic 6 (12): 1114-24. doi:10.1111/j.1600-0854.2005.00347.x. PMID 16262723.
Haraguchi K, Hayashi T, Jimbo T, et al. (2006). "Role of the kinesin-2 family protein, KIF3, during mitosis.". J. Biol. Chem. 281 (7): 4094-9. doi:10.1074/jbc.M507028200. PMID 16298999.
Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.". Mol. Psychiatry 12 (1): 74-86. doi:10.1038/sj.mp.4001880. PMID 17043677.
Pantelidou M, Zographos SE, Lederer CW, et al. (2007). "Differential expression of molecular motors in the motor cortex of sporadic ALS.". Neurobiol. Dis. 26 (3): 577-89. doi:10.1016/j.nbd.2007.02.005. PMID 17418584.