KIF23

From Wikipedia, the free encyclopedia

Kinesin family member 23

Identifiers

KIF23; CHO1; KNSL5; MKLP-1; MKLP1

External IDs

OMIM: 605064 MGI: 1919069 HomoloGene: 11491

Gene ontology
Molecular Function:	• nucleotide binding • microtubule motor activity • ATP binding
Cellular Component:	• nucleus • spindle • kinesin complex • microtubule
Biological Process:	• mitotic spindle elongation • microtubule-based movement • cell cycle • mitosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004856 (mRNA)
NP_004847 (protein)

NM_024245 (mRNA)
NP_077207 (protein)

Location

Chr 15: 67.49 - 67.53 Mb

Chr 9: 61.72 - 61.74 Mb

Pubmed search

[1]

[2]

Kinesin family member 23, also known as KIF23, is a human gene.^[1]

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: KIF23 kinesin family member 23.

[edit] Further reading

Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMID 11416179.
Nislow C, Lombillo VA, Kuriyama R, McIntosh JR (1992). "A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles.". Nature 359 (6395): 543–7. doi:10.1038/359543a0. PMID 1406973.
Lee KS, Yuan YL, Kuriyama R, Erikson RL (1996). "Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1.". Mol. Cell. Biol. 15 (12): 7143–51. PMID 8524282.
Deavours BE, Walker RA (1999). "Nuclear localization of C-terminal domains of the kinesin-like protein MKLP-1.". Biochem. Biophys. Res. Commun. 260 (3): 605–8. doi:10.1006/bbrc.1999.0952. PMID 10403813.
Boman AL, Kuai J, Zhu X, et al. (1999). "Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a GTP-dependent fashion.". Cell Motil. Cytoskeleton 44 (2): 119–32. doi:10.1002/(SICI)1097-0169(199910)44:2<119::AID-CM4>3.0.CO;2-C. PMID 10506747.
Mishima M, Kaitna S, Glotzer M (2002). "Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity.". Dev. Cell 2 (1): 41–54. PMID 11782313.
Kuriyama R, Gustus C, Terada Y, et al. (2002). "CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis.". J. Cell Biol. 156 (5): 783–90. doi:10.1083/jcb.200109090. PMID 11877456.
Kitamura T, Kawashima T, Minoshima Y, et al. (2002). "Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation.". Cell Struct. Funct. 26 (6): 645–51. PMID 11942621.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096.
Matuliene J, Kuriyama R (2005). "Role of the midbody matrix in cytokinesis: RNAi and genetic rescue analysis of the mammalian motor protein CHO1.". Mol. Biol. Cell 15 (7): 3083–94. doi:10.1091/mbc.E03-12-0888. PMID 15075367.
Liu X, Zhou T, Kuriyama R, Erikson RL (2005). "Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.". J. Cell. Sci. 117 (Pt 15): 3233–46. doi:10.1242/jcs.01173. PMID 15199097.
Kurasawa Y, Earnshaw WC, Mochizuki Y, et al. (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.". EMBO J. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMID 15297875.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Zhu C, Bossy-Wetzel E, Jiang W (2005). "Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells.". Biochem. J. 389 (Pt 2): 373–81. doi:10.1042/BJ20050097. PMID 15796717.