KHDRBS3

From Wikipedia, the free encyclopedia

KH domain containing, RNA binding, signal transduction associated 3

Identifiers

KHDRBS3; Etle; SALP; SLM-2; SLM2; T-STAR; etoile

External IDs

OMIM: 610421 MGI: 1313312 HomoloGene: 4780

Gene ontology
Molecular Function:	• RNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • spermatogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006558 (mRNA)
NP_006549 (protein)

XM_979069 (mRNA)
XP_984163 (protein)

Location

Chr 8: 136.54 - 136.73 Mb

Chr 15: 68.76 - 68.93 Mb

Pubmed search

[1]

[2]

KH domain containing, RNA binding, signal transduction associated 3, also known as KHDRBS3, is a human gene.^[1]

[edit] References

^ Entrez Gene: KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3.

[edit] Further reading

Di Fruscio M, Chen T, Richard S (1999). "Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2710-5. PMID 10077576.
Venables JP, Vernet C, Chew SL, et al. (1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.". Hum. Mol. Genet. 8 (6): 959-69. PMID 10332027.
Lee J, Burr JG (2000). "Salpalpha and Salpbeta, growth-arresting homologs of Sam68.". Gene 240 (1): 133-47. PMID 10564820.
Venables JP, Elliott DJ, Makarova OV, et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.". Hum. Mol. Genet. 9 (5): 685-94. PMID 10749975.
Stoss O, Olbrich M, Hartmann AM, et al. (2001). "The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.". J. Biol. Chem. 276 (12): 8665-73. doi:10.1074/jbc.M006851200. PMID 11118435.
Sugimoto Y, Morita R, Amano K, et al. (2001). "T-STAR gene: fine mapping in the candidate region for childhood absence epilepsy on 8q24 and mutational analysis in patients.". Epilepsy Res. 46 (2): 139-44. PMID 11463515.
Kool J, van Zaane W, van der Eb AJ, Terleth C (2002). "Down-regulation of T-STAR, a growth inhibitory protein, after SV40-mediated immortalization.". Cell Growth Differ. 12 (11): 535-41. PMID 11714634.
Reddy TR, Suhasini M, Xu W, et al. (2002). "A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication.". J. Biol. Chem. 277 (8): 5778-84. doi:10.1074/jbc.M106836200. PMID 11741900.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Côté J, Boisvert FM, Boulanger MC, et al. (2003). "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.". Mol. Biol. Cell 14 (1): 274-87. doi:10.1091/mbc.E02-08-0484. PMID 12529443.
Venables JP, Dalgliesh C, Paronetto MP, et al. (2005). "SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome.". Hum. Mol. Genet. 13 (14): 1525-34. doi:10.1093/hmg/ddh165. PMID 15163637.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Cohen CD, Doran PP, Blattner SM, et al. (2005). "Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor.". J. Am. Soc. Nephrol. 16 (7): 1958-65. doi:10.1681/ASN.2005020204. PMID 15901763.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Zhang L, Guo L, Peng Y, Chen B (2006). "Expression of T-STAR gene is associated with regulation of telomerase activity in human colon cancer cell line HCT-116.". World J. Gastroenterol. 12 (25): 4056-60. PMID 16810759.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.