Khat

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Khat
Catha edulis
Conservation status
Least Concern
Scientific classification
Kingdom: Plantae Division: Magnoliophyta Class: Magnoliopsida Order: Celastrales Family: Celastraceae Genus: Catha Species: C. edulis
Binomial name
Catha edulis (Vahl) Forssk. ex Endl.

Khat (Catha edulis, family Celastraceae; Arabic: قات; Somali: Jaad; pronounced [ˈkæt]; Ge'ez ጫት č̣āt), also known as qat, qaat, quat, gat, chat, chad, chaad and miraa, is a flowering plant native to tropical East Africa and the Arabian Peninsula.

Khat contains the alkaloid called cathinone, an amphetamine-like stimulant which causes excitement and euphoria. In 1980 the World Health Organization classified khat as a drug of abuse that can produce mild to moderate psychological dependence, and the plant has been targeted by anti-drug organizations like the DEA.^[1] It is a controlled/illegal substance in many countries.

Contents 1 Description 2 History 3 Cultivation and uses 4 Chemistry and pharmacology 5 Effects 6 Demographics 7 regulation 7.1 World 7.2 Australia 7.3 Canada 7.4 Denmark 7.5 Finland 7.6 France 7.7 The Netherlands 7.8 Germany 7.9 Hong Kong 7.10 Israel 7.11 New Zealand 7.12 Norway 7.13 Somalia 7.14 Sweden 7.15 Switzerland 7.16 United Kingdom 7.17 United States 8 References 9 Notes 10 External links

[edit] Description

Believed to have originated in Oromia, Ethiopia, khat is a slow-growing shrub or small tree that grows to between 1.5 metres and 20 metres tall, depending on region and rainfall, with evergreen leaves 5–10 cm long and 1–4 cm broad. The flowers are produced on short axillary cymes 4–8 cm long, each flower small, with five white petals. The fruit is an oblong three-valved capsule containing 1–3 seeds.

[edit] History

The origins of khat are disputed. Some believe that it is Ethiopian in origin, from where it spread to the hillsides of East Africa and Yemen. Others believe that khat originated in Yemen before spreading to Ethiopia and nearby countries. Sir Richard Burton explains that khat was introduced to the Yemen from Ethiopia in the 15th century.^[2] There is also evidence to suggest this may have occurred as early as the 13th century. Through botanical analysis, Revri (1983) supports Yemen origins of the plant.^[3] From Ethiopia and Yemen the trees spread to Somalia, Arabia, Kenya, Uganda, Tanzania, Congo, Malawi, Zimbabwe, Zambia, and South Africa.^[4] The earliest recorded use of khat medically is believed to be within the New Testament.^[5] The ancient Egyptians considered the khat plant a "divine food" which was capable of releasing humanity's divinity. The Egyptians used the plant for more than its stimulating effects; they used it as a metamorphic process and transcended into "apotheosis", intending to make the user god-like.^{[6] [7]} }

The earliest documented description of khat dates back to the Kitab al-Saidana fi al-Tibb, an 11th century work on pharmacy and materia medica written by Abū Rayhān al-Bīrūnī, a Persian scientist and biologist. Unaware of its origins, al-Bīrūnī wrote that khat is:^[8]

"a commodity from Turkestan. It is sour to taste and slenderly made in the manner of batan-alu. But qat is reddish with a slight blackish tinge. It is believed that batan-alu is red, coolant, relieves biliousness, and is a refrigerant for the stomach and the liver."

In 1854, the Malay writer Abdullah bin Abdul Kadir noted that the custom of chewing Khat was prevalent in Al Hudaydah in Yemen: "I observed a new peculiarity in this city — everyone chewed leaves as goats chew the cud. There is a type of leaf, rather wide and about two fingers in length, which is widely sold, as people would consume these leaves just as they are; unlike betel leaves, which need certain condiments to go with them, these leaves were just stuffed fully into the mouth and munched. Thus when people gathered around, the remnants from these leaves would pile up in front of them. When they spat, their saliva was green. I then queried them on this matter: ‘What benefits are there to be gained from eating these leaves?’ To which they replied, ‘None whatsoever, it’s just another expense for us as we’ve grown accustomed to it’. Those who consume these leaves have to eat lots of ghee and honey, for they would fall ill otherwise. The leaves are known as Kad."^[9]

[edit] Cultivation and uses

The khat plant is known by a variety of names, such as qat and ghat in Yemen, qaat and jaad in Somalia, chat in Oromia and Ethiopia and miraa in Kenya and Tanzania. Khat has been grown for use as a stimulant for centuries in the Horn of Africa and the Arabian Peninsula. There, chewing khat predates the use of coffee and is used in a similar social context. Its fresh leaves and tops are chewed or, less frequently, dried and consumed as tea, in order to achieve a state of euphoria and stimulation; it also has anorectic side-effects. Its use is generally not limited by religion, though the Ethiopian Orthodox Tewahedo Church (along with its Eritrean counterpart) has forbidden Christians from using it due to its stimulating effects. Due to the availability of rapid, inexpensive air transportation, the drug has been reported in England, Wales, Rome, Amsterdam, Canada, Australia, New Zealand^[10] and the United States. The public has become more aware of this drug through media reports pertaining to the United Nations mission in Somalia, where khat use is widespread, and its role in the Persian Gulf.

Khat use has traditionally been confined to the regions where khat is grown, because only the fresh leaves have the desired stimulating effects. In recent years improved roads, off-road motor vehicles and air transport have increased the global distribution of this perishable commodity. Traditionally, khat has been used as a socializing drug, and this is still very much the case in Yemen where khat-chewing is predominantly, although not exclusively, a male habit.^[11] In other countries, khat is consumed largely by single individuals and at parties. It is mainly a recreational drug in the countries which grow khat, though it may also be used by farmers and laborers for reducing physical fatigue and by drivers and students for improving attention. Within the counter-culture segments of the Kenyan elite population, Khat (referred to as veve) is used to counter the effects of a hangover or binge drinking, similar to the use of the coca leaf in South America. In Yemen some women have their own saloons for the occasion, and participate in chewing Khat with their husbands on weekends. In many places where grown, Khat has become mainstream enough for many children to start chewing the plant before puberty.

Khat is so popular in Yemen that its cultivation consumes much of the country's agricultural resources. It is estimated that 40% of the country's water supply goes towards irrigating it, with production increasing by about 10% to 15% every year. Water consumption is so high that groundwater levels in the Sanaa basin are being diminished; because of this, government officials have proposed relocating large portions of the population of Sanaa to the coast of the Red Sea.^[11] One reason for cultivating khat in Yemen so widely is the high income it provides for farmers. Some studies done in 2001 estimated that the income from cultivating khat was about 2.5 million Yemeni rials per hectare, while it was only 0.57 million rials per hectare if fruits were cultivated. This is a strong reason for farmers to prefer to cultivate khat over coffee and fruits.^[12] For this reason, between 1970 and 2000, the area on which khat was cultivated grew from 8,000 hectares to 103,000 hectares. However, these numbers are estimates and the real numbers may be higher.^[12]

In Somalia, the Supreme Islamic Courts Council, which took control of much of the country in 2006, banned khat during Ramadan, sparking street protests in Kismayo. In November 2006, Kenya banned all flights to Somalia, citing security concerns, prompting protests by Kenyan khat growers. The Kenyan Member of Parliament from Ntonyiri, Meru North District stated that local land had been specialized in khat cultivation, that 20 tons worth $800,000 were shipped to Somalia daily and that a flight ban could devastate the local economy.^[13] With the victory of the Provisional Government backed by Ethiopian forces in the end of December 2006, khat has returned to the streets of Mogadishu, though Kenyan traders have noted demand has not yet returned to pre-ban levels.^[14]

[edit] Chemistry and pharmacology

The stimulant effect of the plant was originally attributed to "katin", cathine, a phenethylamine-type substance isolated from the plant. However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviorally active than cathine. In 1975, the related alkaloid cathinone was isolated, and its absolute configuration was established in 1978. Cathinone is not very stable and breaks down to produce cathine and norephedrine. These chemicals belong to the PPA (phenylpropanolamine) family, a subset of the phenethylamines related to amphetamines and the catecholamines epinephrine and norepinephrine.^[15]

Both of khat's major active ingredients - cathine and cathinone - are phenylalkylamines, meaning they are in the same class of chemicals as amphetamines. In fact, cathinone and cathine have a very similar molecular structure to amphetamine.^[16]

When khat leaves dry, the more potent chemical, cathinone, evaporates within 48 hours leaving behind the milder Schedule IV chemical, cathine. Thus, harvesters transport khat by packaging the leaves and stems in plastic bags or wrapping them in banana leaves to preserve their moisture and keep the cathinone potent. It is also common for them to sprinkle the plant with water frequently or use refrigeration during transportation.

When the khat leaves are chewed, cathine and cathinone are released and absorbed through the mucous membranes of the mouth and the lining of the stomach. The action of cathine and cathinone on the reuptake of epinephrine and norepinephrine has been demonstrated in lab animals, showing that one or both of these chemicals cause the body to recycle these neurotransmitters more slowly, resulting in the wakefulness and insomnia associated with khat use.^[17]

Receptors for serotonin show a high affinity for cathinone suggesting that this chemical is responsible for feelings of euphoria associated with chewing khat. In mice, cathinone produces the same types of nervous pacing or repetitive scratching behaviors associated with amphetamines.^[18] The effects of cathinone peak after 15 to 30 minutes with nearly 98% of the substance metabolized into norephedrine by the liver.^[19]

Cathine is somewhat less understood, being believed to act upon the adrenergic receptors causing the release of epinephrine and norepinephrine.^[20] It has a half-life of about 3 hours in humans. Because the receptor effect are similar to those of cocaine medication treatment iof the occasional addiction is similar to that of cocaine. The medication, bromocriptine can reduce cravings and withdrawal symptoms within twenty-four hours. ^[21]

[edit] Effects

Khat consumption induces mild euphoria and excitement. Individuals become very talkative under the influence of the drug and may appear to be unrealistic and emotionally unstable. Khat can induce manic behaviors and hyperactivity. Khat is an effective anorectic and its use also results in constipation. Dilated pupils (mydriasis), which are prominent during khat consumption, reflect the sympathomimetic effects of the drug, which are also reflected in increased heart rate and blood pressure. A state of drowsy hallucinations (hypnagogic hallucinations) may result coming down from khat use as well. Withdrawal symptoms that may follow prolonged khat use include lethargy, mild depression, nightmares, and slight tremor. Long term use can precipitate the following effects: negative impact on liver function, permanent tooth darkening (of a greenish tinge), susceptibility to ulcers, and diminished sex drive. Khat is usually not an addictive drug, although those who are addicted generally cannot stay without it for more than 4-5 days, feeling tired and having difficulty concentrating.^[22] Occasionally a psychosis can result. It resembles a hypermanic state in presentation.^[23]

[edit] Demographics

It is estimated that several million people are frequent users of khat. Many of the users originate from countries between Sudan and Madagascar and in the southwestern part of the Arabian Peninsula, especially Yemen. In Yemen, 80% of the males and 45% of the females were found to be khat users who had chewed daily for long periods of their life. The traditional form of khat chewing in Yemen involves only male users; khat chewing by females is less formal and less frequent. In Saudi Arabia, the cultivation and consumption of khat are forbidden, and the ban is strictly enforced. The ban on khat is further supported by the clergy on the grounds that the Qur'an forbids anything that is harmful to the body. In Somalia, 61% of the population reported that they do use khat, 18% report habitual use, and 21% are occasional users.^{[citation needed]}

Researchers estimate that about 70-80% of Yemenis between 16 and 50 years old chew khat, at least on occasion, and it has been estimated that Yemenis spend about 14.6 million person-hours per day chewing khat. The local researcher Ali Al-Zubaidi has estimated that the amount of money spent on khat has increased from 14.6 billion rials in 1990 to 41.2 billion rials in 1995. Researchers have also estimated that families spend about 17% of their income on khat (the real number may be more.)^[12]

[edit] regulation

[edit] World

In 1965, the World Health Organization Expert Committee on Dependence-producing Drugs' Fourteenth Report noted, "The Committee was pleased to note the resolution of the Economic and Social Council with respect to khat, confirming the view that the abuse of this substance is a regional problem and may best be controlled at that level".^[24] For this reason, khat was not Scheduled under the Single Convention on Narcotic Drugs. In 1980 the World Health Organization classified khat as a drug of abuse that can produce mild to moderate psychological dependence.

[edit] Australia

In Australia, the importation of khat is controlled under the Customs (Prohibited Imports) Regulations. Individual users may apply for several required licenses to import up to 5 kg per month for personal use (primarily immigrants from the Horn of Africa). In 2003, the total number of khat annual permits was 294 and the total number of individual khat permits was 202.

There are two types of import permits. The single use Permit to Import can be used only once and you must request a new permit for each time you wish to import khat. Annual Permits are labeled as such and consist of two pages. Annual Permits allow you to import up to 5 kg once a month for up to twelve months.

– ^{[citation needed]}

There are limited reports that Khat is now a controlled substance in Queensland.^[25]

[edit] Canada

In Canada, cathinone is a controlled substance under Schedule III of the Controlled Drugs and Substances Act (CDSA), meaning it is illegal to possess or obtain unless approved by a medical practitioner. Punishment for the possession of khat could lead to a maximum sentence of three years in prison. The maximum punishment for possession with the purpose of trafficking, or just trafficking, is ten years in prison.^[26][27]

[edit] Denmark

Khat is an illegal and controlled substance from 1993.

[edit] Finland

Khat is classified as an illegal drug and its import, sale and use are punishable in Finland.

[edit] France

Khat is prohibited in France as a stimulant.^[28]

[edit] The Netherlands

In the Netherlands, Khat enjoys a legal status and is sold in several cities, such as Uithoorn and Tilburg.

[edit] Germany

In Germany, Cathine is a controlled substance, and ownership and sale of the plant is illegal. Similar levels of control exist throughout most other European countries.

[edit] Hong Kong

In Hong Kong, both Cathine and Cathinone are regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. It can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined 10,000 Hong Kong dollars. The penalty for trafficking or manufacturing the substance is a 5,000,000 Hong Kong dollars fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a 1,000,000 Hong Kong dollars fine and/or 7 years of jail time.

[edit] Israel

In Israel, Khat is still used by some people of Yemeni origins. Traditionally, it is chewed on Saturday afternoons while reading the Zohar. The leaves are legal, but the cathonine extract pill called Hagigat (a compound of the Hebrew word Hagiga, "party", and Gat, "khat"), is currently illegal. Khat is also grown in the backyards of many Yemenites, but is becoming more popular with other ethnic groups in Israel. The more potent strain from Ethiopia is flown in daily and is available for purchasing. Khat can be purchased at some grocery stores in the Yemenite area of Bnei Brak.

[edit] New Zealand

Khat plant is a Schedule 3 (Class C) drug in New Zealand, but is rarely encountered although occasional seizures at airports have been reported. Mature khat trees which were established before the plant became scheduled in 1998 do not have to be destroyed, but it is illegal to gather the leaves or otherwise prepare the plant for consumption.

[edit] Norway

In Norway Khat is classified as a narcotic drug and is illegal to use, sell and possess. Most users are Somali immigrants and khat is smuggled from the Netherlands and England.^[29] Norwegian Customs seized 3400 kilograms of khat in 2007, an increase from the 1900 kilograms in 2006.^[30]

[edit] Somalia

On November 17, 2006 the usage and distribution of khat was made illegal in Somalia.^[31] The Supreme Islamic Courts Council, which took control of much of the country in that year, banned khat during Ramadan, sparking street protests in Kismayo. In November 2006, Kenya banned all flights to Somalia, citing security concerns, prompting protests by Kenyan khat growers. The Kenyan MP from Ntonyiri, Meru North District stated that local land had been specialized in khat cultivation, that 20 tons worth US$800,000 were shipped to Somalia daily and that a flight ban could devastate the local economy.^[32] With the surprise victory of the Provisional Government backed by Ethiopian forces in the end of December 2006, khat has returned to the streets of Mogadishu, though Kenyan traders have noted demand has not yet returned to pre-ban levels.^[33]

[edit] Sweden

As in Norway, khat is classified as a narcotic drug in Sweden and is illegal to use, sell and possess. According to the police, most users are Somali immigrants and most khat is smuggled in from the Netherlands and England.^[34]

[edit] Switzerland

Khat is prohibited in Switzerland as a stimulant.^[35]

[edit] United Kingdom

Khat is not a controlled substance in the United Kingdom, and recent attempts to reclassify it were rejected.^[36] Because of this, and because of khat's short shelf life, the UK serves as a main gateway for khat being sent by air to North America.^[37]

Khat is used by members of the Somali and Yemeni community (mainly men), which is concentrated in London, Birmingham, Bristol, Cardiff, Manchester and Sheffield. It is currently legal, although there are calls from some sections of the Somali community for it to be banned. In the UK, cathine and cathinone are Class C drugs. The plant Catha edulis is uncontrolled.

[edit] United States

In the United States, Cathine is in Schedule IV and cathinone is in Schedule I of the U.S. Controlled Substance Act. The 1993 DEA rule placing cathinone in Schedule I noted that it was effectively also banning khat.

Cathinone is the major psychoactive component of the plant Catha edulis (khat). The young leaves of khat are chewed for a stimulant effect. Enactment of this rule results in the placement of any material which contains cathinone into Schedule I.

Over 700 pounds of khat was seized by Philadelphia police officers in September 2007. The khat was recovered after being shipped to Philadelphia in containers.^[38] KYW-TV reported that the seizure is the first of its kind in Pennsylvania, although in December 2004, 52 pounds of khat was seized by Pennsylvania State Police in Sugarloaf Township in Luzerne County with an Ethiopian immigrant who had been in the U.S. for 16 years.^[39] Because the drug is cheaper than cocaine, sources said it has an economic appeal.

On December 19, 2007, federal authorities seized more than 400 pounds of khat at the Salt Lake City airport, in Utah. Deputies arrested two men for attempting to import a combined 450 pounds from Ethiopia. Officials say the two tried to pass the khat off as various spices for personal use; If convicted, they could face up to 20 years.

On January 31, 2008, police in Fargo, North Dakota seized 600 pounds of khat at the Hector International Airport. The shipment of khat was allegedly to be transported for distribution in Minneapolis, Minnesota. The drug bust was not announced until June 4, 2008, as the Hennepin County (MN) Sherrif's Office was investigating the case until that time.

[edit] References

• Hilton-Taylor (1998). Catha edulis. 2006 IUCN Red List of Threatened Species. IUCN 2006. Retrieved on 12 May 2006.
• "Somali Islamists are gone -- so "khat" is back!", Reuters, January 2, 2007
• Dale Pendell, Pharmakodynamis: Stimulating Plants, Potions and Herbcraft: Excitantia and Empathogenica, San Francisco: Mercury House, 2002.

[edit] Notes

[edit] External links

• How to chew qat
• BBC News: In pictures... growing khat
• Drugs.com, Complete Khat Information
• Esquire "High in Hell"
• Erowid: Khat Vault
• Growing Catha Edulis (Khat)
• BBC News: Getting to grips with khat in Somaliland
• BBC News: Harmless habit or dangerous drug?
• Australian Government: Therapeutic Goods Administration Khat Importation Kit
• Star Tribune: Dozens Arrested Nationwide in Drug Case
• Qat news page - Alcohol and Drugs History Society (ADHS)
  • Khat news page (ADHS)
• Seattle Times: Seattle arrest - Khat and the Somalian community
• Village Voice article on khat
• Qat cultivation threatening water resources