Talk:Ketoconazole
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[edit] fungistatic / fungicidal
Is this primarily fungistatic or fungicidal? I have found information indicating that this might be fungicidal, whereas fluconazole is primarily fungistatic. If anyone has further information, please add it. I have Valley Fever, and this could save my life. Thanks.
I did my doctorate on resistance to ketoconazole and fluconazole - back when they were just experimental samples from Jannsen and Pfizer. Certainly ketoconazole seemed more toxic than fluconazole. When resistance arose to ketoconazole one could still apply a high enough dose to suppress fungal growth. In the case of fluconazole there was simply no amount of fluconazole that could be added to stop growth. Whether they were fungicidal or fungistatic is a tricky question as it depends on the fungal species and stage of growth. I believe in general that ketoconazole was more lethal as it was less specific and had effects on targets other than 14-alpha demethylase. I would suggest that amphotericin B and other polyene antifungals are considered more fungicidal than the azole family, though of course they are associated with more serious potential side effects. Phil Scrutinator (talk) 19:57, 15 March 2008 (UTC)
[edit] baldness
I have to admit, I had no idea Ketoconazole could treat baldness. I looked it up though and it seems to be true, though to what extent I'm not sure. I didn't want to edit the article itself, but here are a couple of references:
Journal of Dermatological Science Volume 45, Issue 1, January 2007, Page 66, Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity, Shigeki Inui,and Satoshi Itami.
The Journal of Dermatology, 2002 Aug, 29(8):489-98, Comparative efficacy of various treatment regimens for androgenetic alopecia in men, Khandpur, Sujay; Suman, Mansi; Reddy, Belum Sivanagi.
And this one discusses possible mechanisms: Medical hypotheses, 2004, 62(1):112-5, Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men, Hugo Perez, B S,
How about that?
