Ketazolam
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Ketazolam
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| Systematic (IUPAC) name | |
| (R)-11-chloro-2,8-dimethyl-
12b-phenyl-8,12b-dihydro-4H-benzo [f][1,3]oxazino[3,2-d][1,4]diazepine-4,7(6H)-dione |
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| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H17ClN2O3 |
| Mol. mass | 368.8 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Half life | 26-200 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Schedule IV(US) |
| Routes | Oral |
Ketazolam (marketed under brand names Anseren, Anxon, Contamex, Loftran, Marcen, Sedotime, Solatran, Unakalm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Ketazolam is not approved for sale in the United States or Canada. In South Africa, GlaxoSmithKline markets ketazolam under its Solatran trademark.[1] The U.S. Food and Drug Administration warns[2] that in Spain, ketazolam marketed as Marcen may sometimes be mistakenly confused with Narcan.
Ketazolam breaks down in the blood to diazepam which breaks down to demoxepam which breaks down to desmethyldiazepam.[1]
[edit] Brand Names
| NAME |
COUNTRY |
| Anseren |
Italy |
| Ansieten |
Argentina |
| Ansietil |
Chile , Ecuador |
| Marcen |
Spain |
| Sedatival |
Chile |
| Solatran |
South Africa, Bélgica, Suíça |
| Sedotime |
Spain |
| Unakalm |
Portugal, Países Baixos |
[edit] Other names
U 28774; Anxon;[3] Contamex; Loftran; DEA No. 2772[4];
[edit] References
- ^ Joyce JR, Bal TS, Ardrey RE, Stevens HM, Moffat AC (Jun 1984). "The decomposition of benzodiazepines during analysis by capillary gas chromatography/mass spectrometry". Biomed Mass Spectrom. 11 (6): 284. doi:. PMID 6743768.
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