Kernicterus

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Kernicterus Classification and external resources
Bilirubin
ICD-10	P57.
ICD-9	773.4, 774.7
DiseasesDB	7161
MedlinePlus	003243
eMedicine	ped/1247
MeSH	D007647

Kernicterus is damage to the brain centers of infants caused by increased levels of unconjugated-indirect bilirubin which is free (not bound to albumin). This may be due to several underlying pathologic processes. Newborn babies are often polycythemic, meaning they have too many red blood cells. When they break down the cells, one of the byproducts is bilirubin, which circulates in the blood and causes jaundice. Alternately, Rh incompatibility between mother and fetus may cause hemolysis of fetal red blood cells, thereby releasing unconjugated bilirubin into the fetal blood. Since the fetal blood brain barrier is not fully formed, some of this released bilirubin enters the brain and interferes with normal neuronal development. Kernicterus may also be found in infants as a symptom of Crigler-Najjar syndrome type I, a hereditary hyperbilirubinemia that is fatal within 18 months of life.

In adults and older children, jaundice is harmless in and of itself. However, the tissues protecting the brain (the blood-brain barrier) are immature in newborns. Bilirubin penetrates the brain and is deposited in the basal ganglia, causing irreversible damage. Depending on the level of exposure, the effects range from unnoticeable to severe brain damage.

Some medications, such as the antibiotic co-trimoxazole (a combination of trimethoprim/sulfamethoxazole) may induce this disorder in the baby either when taken by the mother or given directly to the baby. Due to displacement of bilirubin from binding sites on serum albumin. The bilirubin is then free to pass into the Central Nervous System, because the baby's blood-brain barrier is not fully developed.

[edit] External links

• BiliTool - Hyperbilirubinemia Risk Assessment for Newborns
• CDC’s National Center on Birth Defects and Developmental Disabilities
• PICK - Parents of Infants and Children with Kernicterus

v • d • e Certain conditions originating in the perinatal period (P, 760-779) Maternal factors and complications Umbilical cord prolapse - Nuchal cord - Chorioamnionitis Length of gestation and fetal growth Small for gestational age - Large for gestational age - Premature birth - Postmature birth Birth trauma Cephalhematoma - Brachial plexus lesion (Erb's palsy, Klumpke paralysis) Respiratory Intrauterine hypoxia - Infant respiratory distress syndrome - Transient tachypnea of the newborn - Meconium aspiration syndrome - pleural disease (Pneumothorax, Pneumomediastinum) - Wilson-Mikity syndrome - Bronchopulmonary dysplasia Cardiovascular Pneumopericardium - Persistent fetal circulation Haemorrhagic and haematological/ hematologic disease Haemorrhagic disease of the newborn - Hemolytic disease of the newborn - Rh disease - Hydrops fetalis - Hyperbilirubinemia (Kernicterus, Neonatal jaundice) Digestive system Ileus - Necrotizing enterocolitis Integument and temperature regulation Erythema toxicum Other disorders Periventricular leukomalacia - Gray baby syndrome - muscle tone (Congenital hypertonia, Congenital hypotonia) - Congenital rubella syndrome