Keowee River
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The Keowee River is created by the confluence of the Toxaway River and the Whitewater River in northern South Carolina. The confluence is today submerged beneath the waters of Lake Jocassee, a reservoir created by Lake Jocassee Dam.
The Keowee River flows out of Lake Jocassee Dam and into Lake Keowee, a reservoir created by Keowee Dam and Little River Dam. The Keowee River flows out of Keowee Dam to join the Twelve Mile River very near a point at current-day Clemson, S. C. where is found the beginning of the Seneca River, a tributary of the Savannah River.
The Keowee River was in the heart of the Cherokee Lower Towns. The principal town of the Lower Towns was called, like the river, Keowee. Other Cherokee towns on the Keowee River included Estatoe and Sugartown (Kulsetsiyi), both of which were named for several different Cherokee towns.