Kenneth Roux

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Dr. Kenneth Roux is an American academic biologist whose research addresses structural analysis of the AIDS Viruses, HIV-1 and SIV, and the antibodies that neutralize them, as well as food-allergen characterization and immunoassay development. He is Kurt G. Hofer Professor of Biological Science at Florida State University, where he is affiliated with the Institute of Molecular Biophysics. Dr. Roux was a member of the research team (along with his research associate Ping Zhu) that used negative stain electron microscopy and cryoelectron microscopy coupled with tomography to produce the first detailed 3-D images of the surface of the AIDS viruses, revealing spike proteins. They show that the three gp120 proteins in each spike consist of a lobed head and a three-legged stalk - and use comparisons with atomic structures to gain insight into the mechanism of fusion.[1] The images produce in his research of HIV structure and genome provide important insights for the development of vaccines that will thwart infection by targeting and crippling the sticky HIV-1 spike proteins.[2]