KCNRG

From Wikipedia, the free encyclopedia

Potassium channel regulator

Identifiers

External IDs

OMIM: 607947 MGI: 2685591 HomoloGene: 35259

Gene ontology
Molecular Function:	• voltage-gated potassium channel activity • identical protein binding
Cellular Component:	• voltage-gated potassium channel complex • membrane
Biological Process:	• potassium ion transport

Orthologs

Human

Mouse

Refseq

NM_173605 (mRNA)
NP_775876 (protein)

NM_001039105 (mRNA)
NP_001034194 (protein)

Location

Chr 13: 49.49 - 49.49 Mb

Chr 14: 60.56 - 60.57 Mb

Pubmed search

[1]

[2]

Potassium channel regulator, also known as KCNRG, is a human gene.^[1]

KCNRG is a soluble protein with characteristics suggesting it forms heterotetramers with voltage-gated K(+) channels (see MIM 176260) and inhibits their function (Ivanov et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: KCNRG potassium channel regulator.

[edit] Further reading

Cho YG, Kim CJ, Song JH, et al. (2006). "Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.". Exp. Mol. Med. 38 (3): 247–55. PMID 16819283.
Skoblov M, Shakhbazov K, Oshchepkov D, et al. (2006). "Human RFP2 gene promoter: unique structure and unusual strength.". Biochem. Biophys. Res. Commun. 342 (3): 859–66. doi:10.1016/j.bbrc.2006.01.187. PMID 16499869.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Corcoran MM, Hammarsund M, Zhu C, et al. (2004). "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse.". Genes Chromosomes Cancer 40 (4): 285–97. doi:10.1002/gcc.20046. PMID 15188451.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ivanov DV, Tyazhelova TV, Lemonnier L, et al. (2003). "A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3.". FEBS Lett. 539 (1-3): 156–60. PMID 12650944.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.