KCNK9

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Potassium channel, subfamily K, member 9
Identifiers
Symbol(s) KCNK9; K2p9.1; KT3.2; MGC138268; MGC138270; TASK-3; TASK3
External IDs OMIM: 605874 MGI: 3521816 HomoloGene: 56758
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 51305 223604
Ensembl ENSG00000169427 ENSMUSG00000036760
Uniprot Q9NPC2 Q3LS21
Refseq NM_016601 (mRNA)
NP_057685 (protein)		 NM_001033876 (mRNA)
NP_001029048 (protein)
Location Chr 8: 140.69 - 140.78 Mb Chr 15: 72.34 - 72.37 Mb
Pubmed search [1] [2]

Potassium channel, subfamily K, member 9, also known as KCNK9, is a human gene.[1]

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KCNK9 potassium channel, subfamily K, member 9.

[edit] Further reading

  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175–84. PMID 11256078. 
  • Goldstein SA, Bayliss DA, Kim D, et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  • Kim Y, Bang H, Kim D (2000). "TASK-3, a new member of the tandem pore K(+) channel family.". J. Biol. Chem. 275 (13): 9340–7. PMID 10734076. 
  • Rajan S, Wischmeyer E, Xin Liu G, et al. (2000). "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor.". J. Biol. Chem. 275 (22): 16650–7. doi:10.1074/jbc.M000030200. PMID 10747866. 
  • Chapman CG, Meadows HJ, Godden RJ, et al. (2001). "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.". Brain Res. Mol. Brain Res. 82 (1-2): 74–83. PMID 11042359. 
  • Vega-Saenz de Miera E, Lau DH, Zhadina M, et al. (2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1.". J. Neurophysiol. 86 (1): 130–42. PMID 11431495. 
  • Talley EM, Bayliss DA (2002). "Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action.". J. Biol. Chem. 277 (20): 17733–42. doi:10.1074/jbc.M200502200. PMID 11886861. 
  • Rajan S, Preisig-Müller R, Wischmeyer E, et al. (2003). "Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.". J. Physiol. (Lond.) 545 (Pt 1): 13–26. PMID 12433946. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mu D, Chen L, Zhang X, et al. (2003). "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.". Cancer Cell 3 (3): 297–302. PMID 12676587. 
  • Pei L, Wiser O, Slavin A, et al. (2003). "Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7803–7. doi:10.1073/pnas.1232448100. PMID 12782791. 
  • Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum.". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID 15197476. 
  • Clarke CE, Veale EL, Green PJ, et al. (2005). "Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc.". J. Physiol. (Lond.) 560 (Pt 1): 51–62. doi:10.1113/jphysiol.2004.070292. PMID 15284350. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kim CJ, Cho YG, Jeong SW, et al. (2005). "Altered expression of KCNK9 in colorectal cancers.". APMIS 112 (9): 588–94. doi:10.1111/j.1600-0463.2004.apm1120905.x. PMID 15601307. 
  • Pocsai K, Kosztka L, Bakondi G, et al. (2006). "Melanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture.". Cell. Mol. Life Sci. 63 (19-20): 2364–76. doi:10.1007/s00018-006-6166-8. PMID 17013562. 
  • Zuzarte M, Rinné S, Schlichthörl G, et al. (2007). "A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3.". Traffic 8 (8): 1093–100. doi:10.1111/j.1600-0854.2007.00593.x. PMID 17547699. 

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Membrane transport protein: ion channels
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