KCNK6

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Potassium channel, subfamily K, member 6

Identifiers

KCNK6; FLJ12282; K2p6.1; KCNK8; TOSS; TWIK-2; TWIK2

External IDs

OMIM: 603939 MGI: 1891291 HomoloGene: 31266

Gene ontology
Molecular Function:	• inward rectifier potassium channel activity • voltage-gated ion channel activity • potassium channel activity • potassium ion binding
Cellular Component:	• membrane fraction • voltage-gated potassium channel complex • membrane • integral to membrane
Biological Process:	• ion transport • potassium ion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004823 (mRNA)
NP_004814 (protein)

XM_993219 (mRNA)
XP_998313 (protein)

Location

Chr 19: 43.5 - 43.51 Mb

Chr 7: 28.93 - 28.94 Mb

Pubmed search

[1]

[2]

Potassium channel, subfamily K, member 6, also known as KCNK6, is a human gene.^[1]

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Tandem pore domain potassium channel

[edit] References

^ ^a ^b Entrez Gene: KCNK6 potassium channel, subfamily K, member 6.

[edit] Further reading

Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175–84. PMID 11256078.
Goldstein SA, Bayliss DA, Kim D, et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
Mahboubi S, Kaufmann JH (1978). "Intramural duodenal hematoma in children. The role of the radiologist in its conservative management.". Gastrointestinal radiology 1 (2): 167–71. PMID 1088718.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Chavez RA, Gray AT, Zhao BB, et al. (1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.". J. Biol. Chem. 274 (12): 7887–92. PMID 10075682.
Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure.". J. Biol. Chem. 274 (17): 11751–60. PMID 10206991.
Pountney DJ, Gulkarov I, Vega-Saenz de Miera E, et al. (1999). "Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.". FEBS Lett. 450 (3): 191–6. PMID 10359073.
Gray AT, Kindler CH, Sampson ER, Yost CS (1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping.". Cytogenet. Cell Genet. 84 (3-4): 190–1. PMID 10393428.
Patel AJ, Maingret F, Magnone V, et al. (2000). "TWIK-2, an inactivating 2P domain K+ channel.". J. Biol. Chem. 275 (37): 28722–30. doi:10.1074/jbc.M003755200. PMID 10887187.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mhatre AN, Li J, Chen AF, et al. (2004). "Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4.". J. Neurosci. Res. 75 (1): 25–31. doi:10.1002/jnr.10839. PMID 14689445.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

[edit] External links

MeSH KCNK6+protein,+human

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v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel