KCNK4

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Potassium channel, subfamily K, member 4
Identifiers
Symbol(s) KCNK4; K2p4.1; TRAAK; TRAAK1
External IDs OMIM: 605720 MGI: 1298234 HomoloGene: 7391
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 50801 16528
Ensembl ENSG00000182450 ENSMUSG00000024957
Uniprot Q9NYG8 Q0VD85
Refseq NM_033310 (mRNA)
NP_201567 (protein)		 NM_008431 (mRNA)
NP_032457 (protein)
Location Chr 11: 63.82 - 63.83 Mb Chr 19: 6.99 - 7 Mb
Pubmed search [1] [2]

Potassium channel, subfamily K, member 4, also known as KCNK4, is a human gene.[1]

Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KCNK4 potassium channel, subfamily K, member 4.

[edit] Further reading

  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175-84. PMID 11256078. 
  • Goldstein SA, Bayliss DA, Kim D, et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.". Pharmacol. Rev. 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  • Lesage F, Maingret F, Lazdunski M (2000). "Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel.". FEBS Lett. 471 (2-3): 137-40. PMID 10767409. 
  • Chapman CG, Meadows HJ, Godden RJ, et al. (2001). "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.". Brain Res. Mol. Brain Res. 82 (1-2): 74-83. PMID 11042359. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Meadows HJ, Chapman CG, Duckworth DM, et al. (2001). "The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK.". Brain Res. 892 (1): 94-101. PMID 11172753. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Ozaita A, Vega-Saenz de Miera E (2003). "Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4. Chromosomal localization, tissue distribution and functional expression.". Brain Res. Mol. Brain Res. 102 (1-2): 18-27. PMID 12191490. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258. 
  • Harinath S, Sikdar SK (2004). "Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels.". Neuropharmacology 46 (5): 750-60. doi:10.1016/j.neuropharm.2003.11.023. PMID 14996553. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 

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v • d • e
Membrane transport protein: ion channels
Ca2+: Calcium channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Other/general