KCNK1

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Potassium channel, subfamily K, member 1
Identifiers
Symbol(s) KCNK1; DPK; HOHO; K2p1.1; TWIK-1; TWIK1
External IDs OMIM: 601745 MGI: 109322 HomoloGene: 1691
Orthologs
Human Mouse
Entrez 3775 16525
Ensembl n/a ENSMUSG00000033998
Uniprot n/a Q99L99
Refseq NM_002245 (mRNA)
NP_002236 (protein)		 NM_008430 (mRNA)
NP_032456 (protein)
Location n/a Chr 8: 128.88 - 128.92 Mb
Pubmed search [1] [2]

Potassium channel, subfamily K, member 1, also known as KCNK1, is a human gene.[1]

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KCNK1 potassium channel, subfamily K, member 1.

[edit] Further reading

  • Goldstein SA, Wang KW, Ilan N, Pausch MH (1998). "Sequence and function of the two P domain potassium channels: implications of an emerging superfamily.". J. Mol. Med. 76 (1): 13-20. PMID 9462864. 
  • Lesage F, Lazdunski M (2000). "Molecular and functional properties of two-pore-domain potassium channels.". Am. J. Physiol. Renal Physiol. 279 (5): F793-801. PMID 11053038. 
  • Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175-84. PMID 11256078. 
  • Goldstein SA, Bayliss DA, Kim D, et al. (2006). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.". Pharmacol. Rev. 57 (4): 527-40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  • Lesage F, Guillemare E, Fink M, et al. (1996). "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.". EMBO J. 15 (5): 1004-11. PMID 8605869. 
  • Lesage F, Mattéi M, Fink M, et al. (1996). "Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43.". Genomics 34 (1): 153-5. PMID 8661042. 
  • Lesage F, Reyes R, Fink M, et al. (1997). "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.". EMBO J. 15 (23): 6400-7. PMID 8978667. 
  • Orias M, Velázquez H, Tung F, et al. (1997). "Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments.". Am. J. Physiol. 273 (4 Pt 2): F663-6. PMID 9362344. 
  • Wang Z, Yue L, White M, et al. (1999). "Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle.". Circulation 98 (22): 2422-8. PMID 9832487. 
  • Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.". Brain Res. Mol. Brain Res. 86 (1-2): 101-14. PMID 11165377. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nicolas MT, Barhanin J, Reyes R, Demêmes D (2004). "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear.". Hear. Res. 181 (1-2): 20-6. PMID 12855359. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rajan S, Plant LD, Rabin ML, et al. (2005). "Sumoylation silences the plasma membrane leak K+ channel K2P1.". Cell 121 (1): 37-47. doi:10.1016/j.cell.2005.01.019. PMID 15820677. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 

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Membrane transport protein: ion channels
Ca2+: Calcium channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
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