KCNJ9

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Potassium inwardly-rectifying channel, subfamily J, member 9
Identifiers
Symbol(s) KCNJ9; GIRK3; KIR3.3
External IDs OMIM: 600932 MGI: 108007 HomoloGene: 37989
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3765 16524
Ensembl ENSG00000162728 ENSMUSG00000038026
Uniprot Q92806 Q544N3
Refseq NM_004983 (mRNA)
NP_004974 (protein)		 NM_008429 (mRNA)
NP_032455 (protein)
Location Chr 1: 158.32 - 158.33 Mb Chr 1: 174.16 - 174.17 Mb
Pubmed search [1] [2]

Potassium inwardly-rectifying channel, subfamily J, member 9, also known as KCNJ9, is a human gene.[1]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9.

[edit] Further reading

  • Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.". Pharmacol. Rev. 57 (4): 509-26. doi:10.1124/pr.57.4.11. PMID 16382105. 
  • Lesage F, Fink M, Barhanin J, et al. (1996). "Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23.". Genomics 29 (3): 808-9. doi:10.1006/geno.1995.9928. PMID 8575783. 
  • Jelacic TM, Sims SM, Clapham DE (1999). "Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3.". J. Membr. Biol. 169 (2): 123-9. PMID 10341034. 
  • Schoots O, Wilson JM, Ethier N, et al. (2000). "Co-expression of human Kir3 subunits can yield channels with different functional properties.". Cell. Signal. 11 (12): 871-83. PMID 10659995. 
  • Vaughn J, Wolford JK, Prochazka M, Permana PA (2000). "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3).". Biochem. Biophys. Res. Commun. 274 (2): 302-9. doi:10.1006/bbrc.2000.3136. PMID 10913335. 
  • Jelacic TM, Kennedy ME, Wickman K, Clapham DE (2000). "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3.". J. Biol. Chem. 275 (46): 36211-6. doi:10.1074/jbc.M007087200. PMID 10956667. 
  • Lavine N, Ethier N, Oak JN, et al. (2003). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.". J. Biol. Chem. 277 (48): 46010-9. doi:10.1074/jbc.M205035200. PMID 12297500. 
  • Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines.". BMC Cancer 5: 104. doi:10.1186/1471-2407-5-104. PMID 16109170. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 

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Membrane transport protein: ion channels
Ca2+: Calcium channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
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