KCNIP4

From Wikipedia, the free encyclopedia

Kv channel interacting protein 4

Identifiers

KCNIP4; CALP; KCHIP4; MGC44947

External IDs

OMIM: 608182 MGI: 1933131 HomoloGene: 23528

Gene ontology
Molecular Function:	• ion channel activity • voltage-gated ion channel activity • potassium channel activity • calcium ion binding • potassium ion binding
Biological Process:	• ion transport • potassium ion transport

Orthologs

Human

Mouse

Refseq

NM_001035003 (mRNA)
NP_001030175 (protein)

NM_030265 (mRNA)
NP_084541 (protein)

Location

Chr 4: 20.34 - 21.56 Mb

Chr 5: 48.68 - 49.81 Mb

Pubmed search

[1]

[2]

Kv channel interacting protein 4, also known as KCNIP4, is a human gene.^[1]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: KCNIP4 Kv channel interacting protein 4.

[edit] Further reading

Holmqvist MH, Cao J, Hernandez-Pineda R, et al. (2002). "Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 1035–40. doi:10.1073/pnas.022509299. PMID 11805342.
Morohashi Y, Hatano N, Ohya S, et al. (2002). "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.". J. Biol. Chem. 277 (17): 14965–75. doi:10.1074/jbc.M200897200. PMID 11847232.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.". Biochem. Biophys. Res. Commun. 319 (3): 720–4. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.". Genomics 86 (5): 581–93. doi:10.1016/j.ygeno.2005.07.001. PMID 16112838.
Chen CP, Lee L, Chang LS (2007). "Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel.". Protein J. 25 (5): 345–51. doi:10.1007/s10930-006-9020-9. PMID 16951992.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Bonne A, Vreede L, Kuiper RP, et al. (2008). "Mapping of constitutional translocation breakpoints in renal cell cancer patients: identification of KCNIP4 as a candidate gene.". Cancer Genet. Cytogenet. 179 (1): 11–8. doi:10.1016/j.cancergencyto.2007.07.005. PMID 17981209.