KCNH1

From Wikipedia, the free encyclopedia

Potassium voltage-gated channel, subfamily H (eag-related), member 1

Identifiers

KCNH1; EAG; EAG1; Kv10.1; MGC142269; h-eag

External IDs

OMIM: 603305 MGI: 1341721 HomoloGene: 68242

Gene ontology
Molecular Function:	• two-component sensor activity • delayed rectifier potassium channel activity • calmodulin binding • potassium ion binding
Cellular Component:	• membrane fraction • voltage-gated potassium channel complex • membrane • integral to membrane
Biological Process:	• two-component signal transduction system (phosphorelay) • regulation of transcription, DNA-dependent • ion transport • potassium ion transport • myoblast fusion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002238 (mRNA)
NP_002229 (protein)

NM_001038607 (mRNA)
NP_001033696 (protein)

Location

Chr 1: 208.92 - 209.37 Mb

Chr 1: 193.89 - 194.21 Mb

Pubmed search

[1]

[2]

Potassium voltage-gated channel, subfamily H (eag-related), member 1, also known as KCNH1 or K_v10.1, is a human gene.^[1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

Voltage-gated potassium channel

[edit] References

^ ^a ^b Entrez Gene: KCNH1 potassium voltage-gated channel, subfamily H (eag-related), member 1.

[edit] Further reading

Gutman GA, Chandy KG, Grissmer S, et al. (2006). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.". Pharmacol. Rev. 57 (4): 473-508. doi:10.1124/pr.57.4.10. PMID 16382104.
Warmke JW, Ganetzky B (1994). "A family of potassium channel genes related to eag in Drosophila and mammals.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3438-42. PMID 8159766.
Hoshi N, Takahashi H, Shahidullah M, et al. (1998). "KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels.". J. Biol. Chem. 273 (36): 23080-5. PMID 9722534.
Occhiodoro T, Bernheim L, Liu JH, et al. (1998). "Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion.". FEBS Lett. 434 (1-2): 177-82. PMID 9738473.
Pardo LA, del Camino D, Sánchez A, et al. (1999). "Oncogenic potential of EAG K(+) channels.". EMBO J. 18 (20): 5540-7. doi:10.1093/emboj/18.20.5540. PMID 10523298.
Schönherr R, Löber K, Heinemann SH (2000). "Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin.". EMBO J. 19 (13): 3263-71. doi:10.1093/emboj/19.13.3263. PMID 10880439.
Cayabyab FS, Schlichter LC (2002). "Regulation of an ERG K+ current by Src tyrosine kinase.". J. Biol. Chem. 277 (16): 13673-81. doi:10.1074/jbc.M108211200. PMID 11834728.
Schönherr R, Gessner G, Löber K, Heinemann SH (2002). "Functional distinction of human EAG1 and EAG2 potassium channels.". FEBS Lett. 514 (2-3): 204-8. PMID 11943152.
Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7986-91. doi:10.1073/pnas.122617999. PMID 12060745.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Farias LM, Ocaña DB, Díaz L, et al. (2004). "Ether a go-go potassium channels as human cervical cancer markers.". Cancer Res. 64 (19): 6996-7001. doi:10.1158/0008-5472.CAN-04-1204. PMID 15466192.
Kang J, Chen XL, Wang H, et al. (2005). "Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel.". Mol. Pharmacol. 67 (3): 827-36. doi:10.1124/mol.104.006577. PMID 15548764.
Ziechner U, Schönherr R, Born AK, et al. (2006). "Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini.". FEBS J. 273 (5): 1074-86. doi:10.1111/j.1742-4658.2006.05134.x. PMID 16478480.
Weber C, Mello de Queiroz F, Downie BR, et al. (2006). "Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference.". J. Biol. Chem. 281 (19): 13030-7. doi:10.1074/jbc.M600883200. PMID 16537547.
Mello de Queiroz F, Suarez-Kurtz G, Stühmer W, Pardo LA (2006). "Ether à go-go potassium channel expression in soft tissue sarcoma patients.". Mol. Cancer 5: 42. doi:10.1186/1476-4598-5-42. PMID 17022811.
Ocorr K, Reeves NL, Wessells RJ, et al. (2007). "KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3943-8. doi:10.1073/pnas.0609278104. PMID 17360457.
Ding XW, Yan JJ, An P, et al. (2007). "Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines.". World J. Gastroenterol. 13 (8): 1257-61. PMID 17451210.
Borowiec AS, Hague F, Harir N, et al. (2007). "IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.". J. Cell. Physiol. 212 (3): 690-701. doi:10.1002/jcp.21065. PMID 17520698.

[edit] External links

MeSH KCNH1+protein,+human

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Membrane transport protein: ion channels

Ca²⁺: Calcium channel	Voltage-dependent calcium channel (L-type/Ca_vα(1.1, 1.2, 1.3, 1.4), N-type, P-type/Ca_vα(2.1), Q-type, R-type, T-type, α₂δ-subunits (1, 2), β-subunits (β1, β2, β3, β4), γ-subunits (γ1, γ2, γ3, γ4) Inositol triphosphate receptor • Ryanodine receptor • Cation channels of sperm • Two-pore channel

Na⁺: Sodium channel	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Na_vβ (1, 2, 3, 4) • Epithelial sodium channel

K⁺: Potassium channel	Voltage-gated (K_vα (1.1, 1.2, 1.3, 1.4, 1.5, 2.1, 3.1, 3.4, 4.1, 4.2, 4.3, 6.1, 7.1, 7.2, 7.3, 7.4, 7.5, 9.3, 10.1, 11.1/hERG) • K_vβ (1, 2), Shaker gene, KCNE1) Calcium-activated (BK channel: α1, β1, β2, β3, β4; SK channel: SK1, SK2, SK3, SK4) Inward-rectifier K_ir (1.1, 2.1, 2.2, 2.3, 2.4, GIRK, 3.1, 3.2, 3.3, 3.4, 4.1, 4.2, 5.1, 6.1, 6.2, 7.1) Tandem pore domain K2P (1, 2, 3, 4, 6, 9, 15, 17)

Cl^-: Chloride channel	Cystic fibrosis transmembrane conductance regulator

Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) • Voltage-dependent anion channel (1)

Cations: TRP	TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)

Other/general	Voltage-gated ion channel • Ligand-gated ion channel • Cyclic nucleotide-gated ion channel (α1, α2, α3, β1, β3, H1, H2, H3, H4) • Stretch-activated ion channel